Mitochondrial Diseases

Mitochondrial Diseases - Causes and Risk Factors

What causes mitochondrial diseases?

Mito can be caused by changes in either the mtDNA or nuclear DNA.

Mito caused by mutations in mtDNA are inherited (passed down) from mothers. Adult-onset mito are often due to mutations in mtDNA.
Mito caused by mutations in nuclear DNA may be inherited from either parent. Childhood-onset mito are often due to mutations in nuclear DNA.

Mito can affect an individual at any age and symptoms vary widely among individuals.

Article contributed by SingHealth Duke-NUS Genomic Medicine Centre

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

Dr Chen Zhiyong

Senior Consultant

MBBS (Singapore), MRCP (United Kingdom), MMed (Internal Medicine)

Clinical Interests: General Neurology

Dr Kaavya Narasimhalu

Consultant

MD, PhD, MRCP, MMed (Int Med)

Clinical Interests: Neurogenetics, General Neurology, Stroke

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