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Prof Lim Kah Leong

Prof Lim Kah Leong


National Neuroscience Institute


​Prof Lim Kah Leong is Visiting Lead (Strategic Alliances) at the National Neuroscience Institute.


  • Ph.D. (Molecular and Cell Biology), Institute of Molecular and Cell Biology, Singapore, 1993-1999
  • B.Sc. Honors (Cell and Molecular Biology), National University of Singapore, 1992-1993
  • B.Sc., National University of Singapore, 1989-1992

Professional Appointments and Committee Memberships

  • ​Head, Department of Physiology, National University of Singapore, 2018 - Present
  • Visiting Lead (Strategic Alliances), National Neuroscience Institute (20% FTE), 2018 - Present
  • Visiting Professor, Northwestern Polytechnical University, China, 2018 - Present
  • Visiting Professor, Nanjing Tech University, China, 2015 - Present
  • Chair, LSI Neurobiology and Ageing Programme Steering Committee, National University of Singapore* (*Acting Head when Programme Leader is away), 2012 - Present
  • Faculty, NUS Graduate School for Integrative Sciences & Engineering, 2011 - Present
  • Associate Professor (Honorary Regular Rank), Duke-NUS Medical School, 2009 - Present


  • ​President Science Award (Team), 2018
  • Singapore Neuroscience Association Distinguished Neuroscientist Award, 2018
  • CeLS Safety Award (GOLD) for outstanding laboratory safety performance, 2017
  • GCEO Outstanding Administrator Award, 2016
  • SingHealth Excellence Award (Distinguished Team Award), 2015
  • Profile featured in ALUMNUS (Alumni Magazine of NUS) under the cover story “The making of a research university”, 2013
  • Khoo Discovery Award, Duke-NUS Graduate Medical School, 2008
  • Outstanding Mentor Award, Science Mentorship Program, Ministry Of Education, 2008
  • Poster Award (Corresponding Author), Gordon Research Conference on Autophagy in stress, development and disease, CA, USA, 2008
  • First IMCB alumnus to be featured on IMCB News Website (April 1st 2008) under the series entitled “Where are they now?”, 2008
  • Merit Award (Poster), 4th Combined Scientific Meeting. NUS, 2003
  • National Science Scholarship International Fellowship, A*STAR, 2002

Research Interests

  • ​Parkinson Disease & Neurodegenerative Diseases


  • Hang, L.T., Thundyil, J., Lim, K.L. AMPK-PGC1-alpha Axis is selectively disrupted in the Ventral Midbrain of Parkin-deficient mice Neuromolecular Medicine 21(1):25-32 (2019)
  • Ci, Q., Zhang, S.Y., Qin, X., Liu, J., Han, L., Li, H., Lim, K.L., Zhang, C.W., Li, L., Huang, W. Polydopamine Dots-Based Fluorescent Nanoswitch Assay for Reversible Recognition of Glutamic Acid and Al3+ in Human Serum and Living Cell ACS Applied Materials and Interface 10(42):35760-35769 (2018) (IF: 8.097)
  • Liu, C., Zhang, C.W., Ang, S.T., Lo, S.Q., Chew, K.C.M., Yu, D., Chai, B., Tan, B., Tsang, F., Tai, Y.K., Liang, M.C., Tan, H.T., Lai, M.K.P., Chung, M.C., Khanna, S., Lim, K.L., Soong, T.W. S-nitrosylation of divalent metal transporter 1 enhances iron uptake to mediate loss of dopaminergic neurons and motoric deficit
    Journal of Neuroscience 38(39):8364-8377 (2018)
  • Serra, A., Gallart-Palau, X., Park, J.E., Lim, G.G., Lim, K.L., Ho, H.W., Tam, J.P, Sze, K.S. Vascular bed molecular profiling by differential systemic decelullarization in vivo (DISDIVO) Arteriosclerosis, Thrombosis, and Vascular Biology 38(10):2396-2409 (2018)
  • Ding, Y., Xin, C., Zhang, C.W., Lim, K.L., Zhang, H., Fu, Z., Li, L., Huang, W. Natural molecules from Chinese Herbs protecting against Parkinson’s disease via anti-oxidative stress Frontiers in Aging Neuroscience Aug 28;10:246 (2018)
  • Weng, M.R., Xie, X., Liu, C., Lim, K.L., Zhang, C.W., Li, L. The Sources of Reactive Oxygen Species and their possible role in the pathogenesis of Parkinson’s Disease Parkinson’s disease Sep 2; 2018:9163040 (2018)
  • Wang, L., Tang, Y., Shi, Y., Deng, S., Lu, G., Zhang, J., Yi, R., Wang, C., Bay, B.H., Lim, K.L., Liou, Y.C., Youle, R., Yap, C., Shen, H.M. PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy Cell Research 28(8):872-873 (2018)
  • Tan, K.K.B, Lim, W.M., Chai, C., Kukumberg, M., Lim, K.L., Goh, E.L.K, Yim, E.K.F. Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Scientific Reports 8 (1): 9567 (2018)
  • Baek, J., Tee, J.K., Pang, Y.Y., Tan, E.Y., Lim, K.L., Ho, H.K., Loo, S.C.J.Improved Bioavailability of Levodopa using Floatable Spray Coated-Microcapsules for the Management of Parkinson’s DiseaseNeuromolecular Medicine 20 (2): 262-270 (2018)
  • Shao, Y., Ma, X., Paira, P., Tan, A., Herr, D.R., Lim, K.L., Ng, C.H., Venkatesan, G., Klotz, K., Federico, S., Spalluto, G., Cheong, S.L., Chen, Y.Z., Pastorin, G.Discovery of indolylpiperazinylpyrimidines with 1 dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson’s disease treatmentPLoS One 13 (1):e0188212 (2018)
  • Liu, C.*, Zhang, C.W.*, Zhou, Y, Wong, W.Q. Stanton L., Lim, K.L., Xiao, Z.C., Dawe, G.APP up-regulates JNK3 expression and contributes to retinal ganglion cell degeneration after optic nerve axotomyCell Death and Differentiation 25 (4): 661-676 (2018)
  • Xiao, B., Goh, J.Y., Xiao, L., Lim, K.L., Liou, Y.C.ROS trigger Parkin/PINK1-dependent mitophagy by inducing mitochondrial recruitment of ParkinJournal of Biological Chemistry 292(40):16697-1670 (2017)
  • Basil., A.H., Sim, J.P.L., Lim, G.G., Lin, S.P., Engelender, S., Lim, K.L.Overexpression of AF-6 protects against dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson’s diseaseFrontiers in Cellular Neuroscience 11: 241 (2017)
  • Xiao, B., Deng, X., Lim, G.G., Xie, S., Zhou, Z.D., Lim, K.L., Tan, E.K.Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondriaCell Death and Disease 8(10):e3097 (2017)
  • Zhang, C.W., Tai, Y.K., Chai, B.H., Chew, K.C.M., Ang, E.T., Fai, T., Tan, B.W.Q., Hong, E.T.E., Abu Bakar, A., Chuang, K.H., Lim, K.L.*, Soong, T.W.* (*co-corresponding)Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the BrainNeuromolecular Medicine 19 (2-3): 375-386 (2017)
  • Ng, C.H., Hang, L.T., Lim, K.L.Mitochondrial homeostasis in Parkinson’s disease- a triumvirate rules?Neural Regeneration Research 12(8):1270-1272 (2017)
  • Chen, Z.C., Zhang, W., Chua, L.L., Li, R., Lin, L., Zhen, C., Angeles, D., Stanton, L, Peng, J., Lim, K.L., Zeng, L., Tan, E.K.Lrrk2 mutations increase APP phosphorylation and promote APP intracellular domain to induce neurotoxicity in Parkinson’s diseaseScience Signaling 10(488). pii: eaam6790 (2017)
  • Prasad, A., Teh, D.B.T., Blasiak, A., Chai, C., Wu, Y., Gharibani, P.M., Yang, I.H., Phan, T.T., Lim, K.L., Yang, H., Liu, X., All, A.H. Static Magnetic Field Stimulation Enhances Oligodendrocyte Differentiation and Secretion of Neurotrophic Factors. Scientific Reports 7 (1): 6743 (2017)
  • Lim, G.G. and Lim, K.L. Parkin-independent Mitophagy – FKBP8 takes the stage EMBO Reports 18: 864-5 (2017)
  • Ng, C.H., Basil, A.H., Hang, L.T., Tan, R., O’Neill S., Zhang, X.D., Yu, F., Lim, K.L. Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson’s disease Neurobiology of Aging 55: 33-37 (2017)

Research Trials