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Assoc Prof Tan Kevin

Assoc Prof Tan Kevin

BMedSci, BMBS, MRCP (United Kingdom), FAMS (Neurology), MS-HPEd

Senior Consultant

National Neuroscience Institute

Specialty: Neurology, Neurology

Clinical Interest: General Neurology, Neuroimmunology, Neuroinfectious Disease

Conditions Treated by this Doctor:
Autoimmune Neurological Diseases, CNS Inflammatory Diseases, HIV Neurology, Multiple Sclerosis, Neurological Infections, Neuromyelitis Optica Spectrum Disorder.

Clinical Appointments

  • Director (Education) National Neuroscience InstituteNational Neuroscience Institute
  • Senior Consultant Department of Neurology National Neuroscience InstituteNational Neuroscience Institute
  • Senior Consultant NNI @CGH Changi General HospitalChangi General Hospital


Dr Kevin Tan is currently a Senior Consultant and Head, Office of Neurological Education at the National Neuroscience Institute (NNI). He received his medical degree from the University of Nottingham, United Kingdom in 1996. He completed basic specialist training in Internal Medicine in 2003, advanced specialist training in Neurology at NNI in 2006, and a Fellowship in Neuroinfectious Disease and Neuroimmunology at Johns Hopkins University in 2008. He has completed a Master of Science in Health Professions Education at MGH Institute of Health Professions (2016). He is active in health professions education and has interests in team-based learning, innovations in Neurology teaching, clinical reasoning and interprofessional education.


  • Fellow of the American Academy of Neurology (FAAN)
  • MS-HPEd (MGH Institute of Health Professions, USA)
  • Fellowship in Neuroinfectious Disease and Neuroimmunology (Johns Hopkins University, USA)
  • MRCP (UK)
  • BMBS (Nottingham, UK)
  • BMedSci (Nottingham, UK)

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Neurology, National Neuroscience Institute (NNI@TTSH)
  • Education Director, National Neuroscience Institute
  • Programme Director, Neuroimmunology and Neuroinflammation, National Neuroscience Institute
  • Vice-Chair (Education), Neuroscience Academic Clinical Programme, SingHealth Duke-NUS Academic Medical Centre, Singapore
  • Adjunct Associate Professor, Duke-NUS Medical School, Singapore
  • Clinical Associate Professor, Yong Loo Lin School of Medicine, Singapore, National University of Singapore


  • NHG Outstanding Education Partners Award, 2018
  • Singapore Health Quality Service Award – Gold Award, 2017
  • GCEO Excellence Award – Outstanding Educator Award (SingHealth), 2016
  • Singapore Health Quality Service Award – Silver Award, 2016
  • Residency In SingHealth Excels (RISE) – Outstanding Faculty Award, 2014
  • Duke-NUS Outstanding Medical Education Research Paper Award, 2012
  • SingHealth Academy Golden Apple – Outstanding Creative Educator (Medical) Award, 2012
  • SingHealth Academy Golden Apple – Programme Innovation Award, 2011

Research Interests

Clinical Research

  • CNS inflammatory diseases
  • Immune-mediated neurological syndromes
  • Neurological infections

Education-related Research

  • Team-based learning
  • Innovations in teaching and assessment
  • Clinical reasoning
  • Interprofessional education


  • Neo S, Yeo T, Chen Z, Ngiam NHW, Lim ET, Tan K, Lim TCC. Acute radiological features facilitate diagnosis and prognosis of anti-N-methyl-d-aspartate receptor (NMDAR) and anti-voltage-gated potassium channel (VGKC) encephalitis in adults. J Neurol Sci. 2020 Dec 15;419:117216. doi: 10.1016/j.jns.2020.117216. Epub 2020 Nov 4. PMID: 33171389.
  • Zellweger RM, Yacoub S, Chan YFZ, Soon D, Shafi H, Ooi ST, Chan M, Jacobson L, Sessions OM, Vincent A, Low JGH, Ooi EE, Wang L, Wijaya L, Tan K; Singapore Neurologic Infections Program (SNIP). Disentangling etiologies of CNS infections in Singapore using multiple correspondence analysis and random forest. Sci Rep. 2020 Oct 26;10(1):18219. doi: 10.1038/s41598-020-75088-4. PMID: 33106525; PMCID: PMC7588471.
  • Koh JS, De Silva DA, Quek AML, Chiew HJ, Tu TM, Seet CYH, Hoe RHM, Saini M, Hui AC, Angon J, Ker JR, Yong MH, Goh Y, Yu WY, Lim TCC, Tan BYQ, Ng KWP, Yeo LLL, Pang YZ, Prakash KM, Ahmad A, Thomas T, Lye DCB, Tan K, Umapathi T. Neurology of COVID-19 in Singapore. J Neurol Sci. 2020 Sep 3;418:117118. doi: 10.1016/j.jns.2020.117118. Epub ahead of print. PMID: 32977228.
  • Goh GX, Tan K, Ang BSP, Wang LF, Tchoyoson Lim CC. Neuroimaging in Zoonotic Outbreaks Affecting the Central Nervous System: Are We Fighting the Last War? AJNR Am J Neuroradiol. 2020 Oct;41(10):1760-1767. doi: 10.3174/ajnr.A6727. Epub 2020 Aug 20. PMID: 32819907.
  • Loh KW, Rotgans JI, Tan K, Tan NCK. Predictors of clinical reasoning in neurological localisation: A study in internal medicine residents. The Asia Pacific Scholar. 2020 Sep;5(3):54-61.
  • Neo S, Kok SS, Tan K, Kumar S. Factors that Predict Delayed Neurological Sequelae of Carbon Monoxide Poisoning from a 10-Year Clinico-Radiological Review. Ann Acad Med Singapore. 2020 May;49(5):331-336. PMID: 32582910.
  • Tang C, Tan K, Lim G, Tan L, Tay KY, Kandiah N, Abdin E, Verma SK. N-Methyl-D-Aspartate (NMDA) Receptor and Voltage-Gated Potassium Channel (VGKC) Antibody-Associated Encephalitides Presenting as First Episode Acute Psychosis. Front Psychiatry. 2019 Dec 13;10:913. doi: 10.3389/fpsyt.2019.00913. eCollection  2019. PubMed PMID: 31920760; PubMed Central PMCID: PMC6923217.
  • Viswanathan S, Appiwatanakul M, Nayak A, Islam B, Khatri B, Pangeran D, Bambardekar H, Maharani K, Tan K, Alexander M, Hussain ME, Adenan MS, Danapaul NA, Khalife N, Ohnmar O, Ong BH, Estiasari R, Hanifa SN, Siritho S, Ng CF, Ratna S, Umapathi T, Thit WM, Ramli Y, Lee YY, Hiew FL. Proceedings of the Inaugural Strategy Meeting for the Establishment of a Southeast Asia Regional Therapeutic Plasma Exchange Consortium for Neurological Disorders. Ther Apher Dial. 2019 Jun;23(3):289-297. doi: 10.1111/1744-9987.12806. Epub 2019 May 21. PubMed PMID:30927331.
  • Yeo T, Chen Z, Yong KP, Wong PYW, Chai JYH, Tan K. Distinction between anti-VGKC-complex antibody positive patients with and without anti-LGI1/CASPR2 antibodies. J Neurol Sci. 2018 Aug 15;391:64-71. doi: 10.1016/j.jns.2018.05.020. Epub 2018 May 27. PubMed PMID: 30103974.
  • Tan K, Chin HX, Yau CWL, Lim ECH, Samarasekera D, Ponnamperuma G, Tan NCK. Evaluating a bedside tool for neuroanatomical localization with extended-matching questions. Anat Sci Educ. 2018 May 6;11(3):262-269. doi: 10.1002/ase.1741. Epub 2017 Sep 22. PubMed PMID: 28941011.
  • Yeo T, Chen Z, Chai JYH, Tan K. Detection of LGI1 and CASPR2 antibodies with a commercial cell-based assay in patients with very high VGKC-complex antibody levels. J Neurol Sci. 2017 Jul 15;378:85-90. doi: 10.1016/j.jns.2017.04.045. Epub 2017 Apr 28. PubMed PMID: 28566186.
  • Lin XL, Yu WY, Liauw L, Chander RJ, Soon WLE, Lee HY, Tan K. Clinico-Radiological Features Distinguish Tumefactive Multiple Sclerosis from CNS Neoplasms. Neurol Clin Pract. 2017;7:53-64. doi:10.1212/CPJ.0000000000000319. Epub 2016 Nov 4.
  • Koelman DL, Benkeser DC, Xu Y, Neo SX, Tan K, Katsuno M, Sobue G, Natsume J, Chahin S, Mar SS, Venkatesan A, Chitnis T, Hoganson GM, Yeshokumar AK, Barreras P, Majmudar B, Carone M, Mateen FJ. Acute disseminated encephalomyelitis in China, Singapore and Japan: a comparison with the USA. Eur J Neurol. 2017 Feb;24(2):391-396. doi: 10.1111/ene.13220.
  • Tan K, Wijaya L, Chiew HJ, Sitoh YY, Shafi H, Chen RC, Goh CK, Lim CCT. Diffusion-weighted MRI abnormalities in an outbreak of Streptococcus agalactiae Serotype III, multilocus sequence type 283 meningitis. J Magn Reson Imaging. 2017 Feb;45(2):507-514. doi: 10.1002/jmri.25373.
  • Prerna A, Lim JY, Tan NW, Isa MS, Oh HM, Yassin N, Low CY, Chan DW, Chong CY, Leo YS, Chow AL, Tambyah PA, Tan K. Neurology of the H1N1 pandemic in Singapore: a nationwide case series of children and adults. J Neurovirol. 2015 Oct;21(5):491-9. doi: 10.1007/s13365-015-0341-3.
  • Ng ASL, Tan K. Methotrexate is effective for the treatment of Neuromyelitis Optica spectrum disorders in Asian patients. Clinical and Experimental Neuroimmunology. 2015;6:149-153.
  • Tan K, Tan NC, Kandiah N, Samarasekera D, Ponnamperuma G. Validating a script concordance test for assessing neurological localization and emergencies. Eur J Neurol. 2014 Nov;21(11):1419-22. doi: 10.1111/ene.12373.
  • Kam KQ, Tan GS, Tan K, Lim EC, Koh NY, Tan NC. Neurophobia in medical students and junior doctors--blame the GIK. Ann Acad Med Singapore. 2013 Nov;42(11):559-66.
  • Tan NC, Kandiah N, Chan YH, Umapathi T, Lee SH, Tan K. A controlled study of team-based learning for undergraduate clinical neurology education. BMC Med Educ. 2011 Oct 30;11:91. doi: 10.1186/1472-6920-11-91.
  • Tan K, Prerna A, Leo YS. Surveillance of H1N1-related neurological complications. Lancet Neurol. 2010 Feb;9(2):142-3. doi: 10.1016/S1474-4422(10)70015-6.
  • Ratchford JN, Shore W, Hammond ER, Rose JG, Rifkin R, Nie P, Tan K, Quigg ME, de Lateur BJ, Kerr DA. A pilot study of functional electrical stimulation cycling in progressive multiple sclerosis. NeuroRehabilitation. 2010;27(2):121-8. doi: 10.3233/NRE-2010-0588.
  • Kandiah N, Tan K, Lim CC, Venketasubramanian N. Hyperglycemic choreoathetosis: role of the putamen in pathogenesis. Mov Disord. 2009 Apr 30;24(6):915-9. doi: 10.1002/mds.22277.
  • Tan K, Roda R, Ostrow L, McArthur J, Nath A. PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology. 2009 Apr 28;72(17):1458-64. doi: 10.1212/01.wnl.0000343510.08643.74.
  • Tan K, Patel S, Gandhi N, Chow F, Rumbaugh J, Nath A. Burden of neuroinfectious diseases on the neurology service in a tertiary care center. Neurology. 2008 Oct 7;71(15):1160-6. doi: 10.1212/01.wnl.0000327526.71683.b7.
  • Kandiah N, Tan K, Pan AB, Au WL, Venketasubramanian N, Tchoyoson Lim CC, Tan NC. Creutzfeldt-Jakob disease: which diffusion-weighted imaging abnormality is associated with periodic EEG complexes? J Neurol. 2008 Sep;255(9):1411-4. doi: 10.1007/s00415-008-0934-3.
  • Tan NC, Tan K. 'Who wants to be a neurologist?' An undergraduate quiz. Med Educ. 2008 May;42(5):522. doi: 10.1111/j.1365-2923.2008.03056.x.

Research Trials

  • Singapore Neurologic Infections Program (SNIP) (Singapore Infectious Diseases Initiative [SIDI]
  • Assessing the feasibility of an Extended-Matching Questions (EMQ) evaluation tool for neuroanatomical localization – a multi-center study
  • Epidemiology and Etiology of Acute Infectious Neurologic Disease (AIND) in Singapore
  • Assessment of clinical reasoning: A pilot study of the script concordance test
  • PREMIERE Registry
  • Enhancing the teaching and application of neuroanatomical localization with a concise Précis tool
  • The frequency of anti-NMDA receptor and anti-VGKC encephalitides in patients presenting with acute psychosis
  • Oracle MS Study
  • Neuroimmunology Database and Tissue Repository