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Dr Sun Alfred Xuyang

Dr Sun Alfred Xuyang

​Ph.D., B.S.

National Neuroscience Institute


​Dr Alfred Sun Xuyang is Junior Principal Investigator at the National Neuroscience Institute.


  • ​Genome Institute of Singapore, Postdoc, 2016
  • Stanford University, Ph.D., 2012
  • Duke University, B.S., 2005

Professional Appointments and Committee Memberships

  • Junior Principal Investigator, National Neuroscience Institute, 2018 - Present
  • Senior Research Fellow, Genome Institute of Singapore, 2012 - Present
  • Singapore Stem Cell Society, 2006 - Present


Research Interests

  • ​Stem cells
  • Human neurological and neurodegenerative diseases
  • Disease modeling
  • Gene therapy
  • Organoids
  • Regenerative medicines


  • ​Jo J, Tran HD, Yu W, Yang L, Saw TY, Sun AX, Yaw LP, Lokman H, Ong WY, Lim GGY, Lim KL, Tan EK, Ng HH, Je HS. Generation of pathophysiological midbrain organoid models in Parkinson’s disease. Submitted to Cell Stem Cell, Oct. 2018
  • Sun AX*, Yuan Q*, Fukuda M, Yu W, Yan HD, Lim GGY, Nai HH, D’Agostino GA, Tran HD, Itahana Y, Wang D, Lokman H, Itahana I, Lim SWL, Tang J, Cook SA, Rackham OJL, Lim CT, Tan EK, Ng HH, Lim KL, Jiang YH, Je HS. BK Channelopathy in human neuronal models of Angelman Syndrome. Submitted to Science, Sept. 2018 (co-first author and co-corresponding author)
  • Zhou W, Ma D, Sun AX, Tran HD, Ma DL, Singh BK, Zhou J, Zhang J, Wang D, Zhao Y, Yen PM, Goh E, Tan EK. PD-linked CHCHD2 mutations impair CHCHD10 and MICOS complex leading to mitochondria dysfunction. Hum Mol Genet. 2018 Nov 29.
  • Sun AX, Tan EK. Towards better cellular replacement therapies in Parkinson disease. Journal of Neuroscience Research. 2018 Feb 96(2):219-221.
  • Zhuang P, Sun AX*, An J, Chua CK, Chew SY. 3D neural tissue models: From Spheroids to bioprinting. Biomaterials. 2018 Feb 154:113-133. (co-first author)
  • Sun AX*, Ng HH, Tan EK. Translational potential of human brain organoids. Annals of Clinical and Translational Neurology. 2018 Jan 20;5(2):226-235.
  • Sun AX*, Yuan Q, Tan S, Xiao Y, Wang D, Khoo AT, Sani L, Tran HD, Kim P, Chiew YS, Lee KJ, Yen YC, Ng HH, Lim B, Je HS. Direct induction and functional maturation of forebrain GABAergic neurons from human pluripotent stem cells. Cell Reports. 2016 Aug 16;16(7):1942-53. (*co-corresponding author)
  • Jo J, Xiao Y*, Sun AX*, Cukuroglu E*, Tran HD, Göke J, Tan ZY, Saw TY, Tan CP, Lokman H, Lee Y, Kim D, Ko HS, Kim SO, Park JH, Cho NJ, Hyde TM, Kleinman JE, Shin JH, Weinberger DR, Tan EK, Je HS, Ng HH. Midbrain-like organoids from human pluripotent stem cells contain functional dopaminergic and neuromelanin-producing neurons. Cell Stem Cell. 2016 Aug 4;19(2):248-57.(*equal contributions)
  • Wang JL, Shamah SM, Sun AX, Waldman ID, Haggarty SJ, Perlis RH. Label-free, live optical imaging of reprogrammed bipolar disorder patient-derived cells reveals a functional correlate of lithium responsiveness. Transl Psychiatry. 2014 Aug 26;4:e428
  • Staahl BT, Tang J, Wu W, Sun AX, Gitler AD, Yoo AS, Crabtree GR. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013 Jun 19;33(25)
  • Sun AX, Crabtree GR, Yoo AS. MicroRNAs: regulators of neuronal fate. Current opinion in cell biology. 2013 Jan 29.
  • Yoo AS*, Sun AX*, Li L*, Shcheglovitov A*, Portmann T, Li Y, Lee-Messer C, Dolmetsch RE, Tsien RW, Crabtree GR. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 2011, 476(7359):228-31 (*co-first author, highlighted in Nature News and Views; Faculty 1000 recommended)
  • Motoda L, Osato M, Yamashita N, Jacob B, Chen LQ, Yanagida M, Ida H, Wee HJ, Sun AX, Taniuchi I, Littman D, Ito Y. Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult. Stem Cells. 2007 Dec;25(12):2976-86.

Research Trials