Asst Prof Xiao Bin

Dr Xiao is a Principal Investigator at the National Neuroscience Institute (NNI) and an Assistant Professor at Duke-NUS Medical School. A trained neurologist specialising in movement disorders, he directs research on biomarkers and actionable targets in neurodegenerative diseases. His objective is to develop therapeutic options that may halt or reverse the underlying pathological processes of these conditions, including Parkinson’s disease. By integrating clinical observation with translational studies, his work seeks to identify disease-signalling biomarkers and advance treatments that address disease biology, moving beyond symptomatic relief to improve outcomes for patients.

• Ph.D., National University of Singapore, 2014
• ​MBBS, Central South University, China, 2001

• Principal Investigator, National Neuroscience Institute
• Assistant Professor, Duke-NUS Medical School, Singapore

• Transition Award, National Medical Research Council, 2023
• Gold Award, Best Junior Researcher, National Neuroscience Institute, 2022

• Neurotherapeutics
• Biomarkers
• Neurodegeneration

• Xiao B, Tan EK. Prasinezumab slows motor progression in Parkinsons disease: beyond the clinical data. NPJ Parkinsons Dis. 2025 Feb 19;11(1):31.
• Tan B, Ng E, Sun QY, et al. LINC00323 variant is associated with increased risk of essential tremor. Ann Clin Transl Neurol. 2025 Apr 30.
• Huang Z, Zheng J, Yuan F, et al. Fibrinogen exacerbates alpha-synuclein aggregation and mitochondrial dysfunction via alpha5beta3 integrin in Parkinson's disease. J Adv Res. 2025 May 25.
• Mai AS, Chao Y, Xiao B, et al. Risk of Suicidal Ideation and Behavior in Individuals With Parkinson Disease: A Systematic Review and Meta-Analysis. JAMA Neurol. Jan 1 2024;81(1):10-18.
• Xiao B, Deng X, Ng EY, et al. Parkinson's disease genome-wide association study-linked PARK16 variant is associated with a lower risk of cognitive impairment: A 4-year observational study. Eur J Neurol. Sep 2023;30(9):2874-2878.

Link to Google Scholar Profile for Full List of Publications: ‪Bin Xiao - ‪Google Scholar