Clin Asst Prof Jonathan Lai

MBBS (Hons), MRCP (UK), M Med (internal Medicine)

Consultant

National Neuroscience Institute

Specialty: Neurology

Make an Appointment

About Doctor

Languages Spoken

Education and Training

Professional Appointments and Committee Memberships

Awards

Research Trials/Clinical Trials

Publications

Conditions Treated By This Doctor

Stroke

Clinical Interests

General Neurology, Neurointensive Care, Stroke

Clinical Appointments

Consultant

Neurology

Consultant

NNI @CGH

Academic Appointments

Clinical Asst Professor

Neuroscience Academic Clinical Programme

About Doctor

Dr Jonathan Lai is a Consultant, Department of Neurology, at the National Neuroscience Institute (NNI@TTSH).

He graduated in Medicine from Monash University, Australia in 2012. In 2018, he completed his Internal Medicine Residency programme with the National Healthcare Group and subsequently completed his Neurology Senior Residency training with SingHealth in 2021.

Languages Spoken

English
Chinese

Education and Training

Registered Physician in Neurovascular Interpretation, American Society of Neuroimaging, 2025
Specialty Certificate in Neurology (United Kingdom), 2020
Masters of Medicine, Internal Medicine, National University of Singapore, 2016
Membership of the Royal College of Physicians (United Kingdom), 2016
MBBS (Honours), Monash University, Melbourne, Australia, 2012

Professional Appointments and Committee Memberships

Consultant, Department of Neurology, National Neuroscience Institute (NNI@TTSH)
Clinical Assistant Professor, Duke-NUS Medical School
Neurology Phase 2 Clerkship Coordinator, Duke-NUS Medical School
Clinical Core Faculty Member, Singhealth Neurology Senior Residency Program
Neurology Lead, NNI Neurology Hospital Clinical Program
Clinical Lecturer, Yong Loo Lin School of Medicine
Clinical Educator, Lee Kong Chian School of Medicine
Neurology Posting Lead for Changi General Hospital, Lee Kong Chian School of Medicine
Neurology Medical Education Lead, Changi General Hospital
Member, Medical Audit Committee, Changi General Hospital
Chief Resident, Singhealth Neurology Senior Residency at Tan Tock Seng Hospital, 2020
Chief Resident, National Healthcare Group (NHG) Internal Medicine Residency, 2018 to 2019
Assistant Chief Resident, National Healthcare Group (NHG) Internal Medicine Residency, 2017 to 2018

Awards

SingHealth 10-year Long Service Award, SingHealth, 2025
Gold Award, Singapore Health Quality Service Awards, 2025
Star Award, NNI Quality Service Award, 2024
Gold Award, NNI Service Quality Award 2023
Silver Award, Singapore Health Quality Service Awards, 2022
Gold Award, Quality and Innovation Project Award, NNI Quality Day, 2021
Outstanding Resident Awards, Residency in SingHealth Excels (RiSE) Awards, Singapore, 2020
National Healthcare Group Teaching Award for Junior Doctors National Healthcare Group, 2017

Research Trials/Clinical Trials

A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Efficacy and Safety of MLC1501 in Patients with Stroke – Co-investigator
A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack (LIBREXIA-STROKE) – Co-investigator
TEMPO-2 – A randomized controlled trial of tenecteplase (TNK-tPA) versus standard of care for minor ischemic stroke with proven occlusion – Co-investigator
ESCAPE-NEXT trial – Co-investigator
Confirm Rx™ Insertable Cardiac Monitor SMART Registry (Cryptogenic Stroke Sub-study) – Co-investigator

Publications

For a full list of publications, visit: Lai Yexian Jonathan - Google Scholar ‪

Gareth Zigui Lim; Leong Gen Yap; Jonathan Yexian Lai; Tianrong Yeo; Yi Jayne Tan; Jia Nee Foo; Javier Alegre-Abarrategui; Adeline SL Ng. Clinical Reasoning: A 69-Year-Old Man With Rapid Cognitive Decline and Abnormal Movements, Neurology March 10, 2026 issue 106 (5) e2146
Lim Gareth; Tang Aaron; Wing Tracey; Lai Jonathan. Agony of akathisia: a case of sodium valproate-induced akathisia. BMJ case reports 2024; 17(1)
Jonathan Yexian Lai, Rui Ya Soh, Kim Hoong Yap, Kundan Saripalli, Gareth Zigui Lim, Adeline Su Lyn Ng, Kevin Tan, Tianrong Yeo. Transient organising pneumonia at the onset of AQP4-antibody neuromyelitis optica spectrum disorder: A case series and literature review. Neuroimmunology Reports 2023; 3
Lim Gareth Zigui; Lai Jonathan Yexian; Seet Christopher Ying Hao; Tham Carol Huilian; Venketasubramanian Narayanaswamy; Tan Benjamin Yong Qiang; Jing Mingxue; Yeo Joshua Yee Peng; Myint May Zin; Sia Ching-Hui; Teoh Hock Luen; Sharma Vijay Kumar; Chan Bernard Poon Lap; Yang Cunli; Makmur Andrew; Ong Shao Jin; Yeo Leonard Leong Litt. Revolutionizing the Management of Large-Core Ischaemic Strokes: Decoding the Success of Endovascular Therapy in the Recent Stroke Trials. Journal of cardiovascular development and disease 2023; 10(12)
Poh Mervyn Qi Wei; Tham Carol Huilian; Chee Jeremiah David Ming Siang; Saffari Seyed Ehsan; Tan Kenny Wee Kian; Tan Li Wei; Ng Ebonne Yulin; Yeo Celestia Pei Xuan; Seet Christopher Ying Hao; Xie Joanne Peiting;Lai Jonathan Yexian; Singh Rajinder; Tan Eng-King; Tu Tian Ming Predicting Atrial Fibrillation after Ischemic Stroke: Clinical, Genetics, and Electrocardiogram Modelling. Cerebrovascular diseases extra 2023; 13(1):9-17
Yong Christl S K; Maniam Ethan Jian-Hui; Chang Cheryl W L;Lai Jonathan Yexian; Ho Cyrus Su Hui Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient. Frontiers in neurology 2023; 14:1239576
Tan You-Jiang; Ng Gee-Jin; Yexian Lai Jonathan; Narasimhalu Kaavya. Sulcal artery syndrome: A Three-patient series and review of literature. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2021; 88:47-51
Yexian Jonathan Lai, Oh Chia Theng Daniel. Thrombolysis may be safely given in an acute stroke patient with Marfan’s syndrome: A case report. Neurology Asia 2020; N.A(25):383-386