Dr Zhou Zhi Dong is a Principal Investigator and Clinician Scientist at the National Neuroscience Institute and an Assistant Professor at Duke-NUS Medical School. With over two decades of experience in neuroscience, his research focuses on the molecular and cellular mechanisms underlying Parkinson’s disease and related neurodegenerative disorders. He has made seminal contributions in uncovering the pathological roles of dopamine oxidation, mitochondrial dysfunction, iron metabolism, and LRRK2 mutations, and identified the tyrosine hydroxylase–dopamine pathway as a novel therapeutic target.         

Dr Zhou has published more than 70 peer-reviewed articles in leading journals such as Nature Reviews Neurology, Molecular Neurodegeneration, and Science Signaling, and has been consistently supported by competitive NMRC and SingHealth–Duke NUS grants. He has also contributed extensively to the scientific community as a reviewer and editorial board member for over 100 international journals. In addition to his research achievements, Dr. Zhou is deeply committed to mentorship, having supervised more than 80 students and trainees across undergraduate, graduate, and doctoral levels. Through his leadership, scholarship, and collaborative approach, he has significantly strengthened Singapore’s neuroscience research landscape and advanced the global understanding of Parkinson’s disease pathogenesis and therapy.

• ​Ph.D. in Biochemistry & Molecular Biology / Biophysics, Shanghai Branch, Chinese Academy of Science, (P. R. China), 2003
• Post-graduate Clinical Training in Internal Medicine, the First People's Hospital of Nantong City, Jiangsu Province, P. R. China, 1991-1996
• Bachelor of Medicine, in Medicine, Nantong Medical University, (P. R. China), 1991

• Principal Investigator, National Neuroscience Institute
• Assistant Professor, NBD, Duke-NUS Medical School, Singapore

• Best Junior Research Award (Clinical Research Category), NNI-Neuroscience ACP Research Day, 2024
• Human Longevity Catalysis Award, NMRC, 2024
• NNI Publish! Award, NNI-Neuroscience ACP Research Day, 2023
• Course Certificate in Translational Medicine, Duke-NUS, 2023
• Human Longevity Catalysis Award, NMRC, 2022
• Bronze – Best Junior Researcher Award (Basic Science & Translational Research), NNI-Neuroscience ACP Research Day, 2022
• Khoo Bridge Funding Award, Duke-NUS, 2021
• Bronze – Best Junior Researcher Award (Basic Science & Translational Research), NNI-Neuroscience ACP Research Day, 2020
• Transition Award, NMRC, 2013
• Winner of Biotech Fair, the Second Prize, MOE, 2011
• Winner of Biotech Fair, the Third prize, MOE, 2006

• Identification and verification of therapeutic targets, biomarkers and neuro-protective agents for Parkinson disease and other neurodegenerative diseases

• Zifeng Huang, Hui Zhong, Yingqiong Lu,,,Zhidong Zhou, et al. Neurotherapeutics, in press, IF: 6.85
• Rosalie, R; EK Tan and Zhidong Zhou, Stem Cell Research & Therapy, in press, IF: 7.39
• SC Gu, Thomas Welton, and ZD Zhou. Briefings in Bioinformatics. 2025. *, Corresponding author. IF: 7.7
• Yi Min Wang, ZD Zhou, Eng King Tan, Sleep Medicine Clinics 2025. IF: 3.1
• Huang Zifeng, Zheng Jialing,,,, ZD Zhou et al. Journal of advanced research 2025. IF:11.4
• BIchler, Z, Vanan Sarvin,,,ZD Zhou, International Journal of Molecular Sciences. 2025. 26 (8), IF 4.9
• ZD Zhou, et al. Pharmacological Research, 2025, 107770. IF: 10.1
• B Xiao, ZD Zhou, YX Chao, EK Tan - Neurologic Clinics, 2025. IF 2.4
• G Saw, LX Yi, EK Tan, ZD Zhou. International Journal of Molecular Sciences. 2025. 26 (2), 508. *, Corresponding author. IF 4.9
• LX Yi, EK Tan, ZD Zhou. International Journal of Molecular Sciences 2025. 26 (1), 389. *, Corresponding author. IF 4.9
• Yi LX, Zhou ZD (2025). Neural Regen Res 2025, 20 (11), 3193-3206. *, Corresponding author. IF: 6.90
• HaiTao Tu, Zhi Dong Zhou, et al. Mol Neurodegeneration. 2024. 19 (1), 91. IF: 17.5
• ZD Zhou, AH Kihara. IJMS 2024, 11334. *, Corresponding author. IF: 4.9
• JJL Low, BJW Tan, LX Yi, ZD Zhou, EK Tan. Journal of Translational Medicine 2024, 22 (1), 961. IF: 8.0
• Y Yang, ZD Zhou, LX Yi, BJW Tan, EK Tan. Ageing Research Reviews, 2024, 102381, IF: 12.4.
• BJW Tan, ZD Zhou, LL Chan, EK Tan, 2024. Environmental Science and Pollution Research, 1-2. IF: 5.90
• LX Yi,, , ZD Zhou. Ageing Research Reviews, 2024, 102339. *, Corresponding author. IF: 10.8
• LX Yi, EK Tan, ZD Zhou, Journal of Translational Medicine 2024, 22, 430:7. *, Corresponding author. IF: 8.0
• LX Yi,, ZD Zhou, International Journal of Molecular Sciences, 2024; 25, 4643. IF: 4.9. *, Corresponding author.
• Brendan Jen-Wei Tan,, Zhi Dong Zhou. Obesity Facts. 2024. IF: 3.4 *, Corresponding author
• BJW Tan, Zhi Dong Zhou, EK Tan. Canadian Journal of Neurological Sciences, in 1-31. 2024. IF: 3.2
• AS Mai, Zhi Dong Zhou, EK Tan. JAMA Neurol. 2024;81(1):10-18. IF: 29.907.
• Zhi Dong Zhou, LX Yi, EK Tan. Cell Reports Medicine 4 (6). 2023. IF: 14.70. *, Corresponding author
• Zhi Dong Zhou, LX Yi, et al. Translational Neurodegeneration, 44 (2023). IF: 15.4. *, Corresponding author
• Zhi Dong Zhou & AH Kihara. IJMS 13721. 2023. IF: 4.9. *, Corresponding author.
• Aaron Shengting Mai, Yinxia Chao, Bin Xiao, Zhidong Zhou, et al. JAMA Neurology. 2023. IF: 29.907.
• Zhi Dong Zhou, et al. Cell Mol Life Science, 2022 Nov 21;79(12):599. IF: 6.71. *, Corresponding author
• Zhi-Wei Zhang, Hai Tao Tu,, Zhi Dong Zhou, et al. Science Signaling. 2022 Aug 23;15(748):eabk3411. IF: 9.714.
• Zhi Dong Zhou, et al. Nature Reviews Neurology. 2022. 18 (8), 145-157 IF: 44.711.
• Zhi Dong Zhou,. Frontiers in Cellular Neuroscience. 2022; 16: 870631. IF: 6.147
• H Liu, B Deng, Z Wu, H Zhou, Y Chen, G Weng, S Zhu,, Zhi Dong Zhou.. 2022. EClinicalMedicine. IF: 17.033
• For Full List of Publications: Zhou Zhi Dong‬ - ‪Google Scholar‬‬‬