Tan Eng King
MBBS, MRCP (United Kingdom), FRCP (Edinburgh), FAMS (Neurology)
Director of ResearchSenior Consultant, Department of NeurologyProfessor and Deputy Director, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical SchoolCo-Principal Investigator, Regenerative Medicine
Lim Kah Leong
Assistant Director of ResearchPrincipal Research Scientist, Department of ResearchAssociate Professor, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical SchoolCo-Principal Investigator, Regenerative Medicine
National Neuroscience Institute11 Jalan Tan Tock Seng, Singapore 308433Tel: (65) 6321 4006 (Tan Eng King) / (65) 6357 7520 (Lim Kah Leong)
Dr. Zeng Li, Ph.D., Senior Research ScientistDr. Chai Chou, Ph.D., Associate Research ScientistDr. Ma Dongrui, M.D., Ph.D., Postdoctoral FellowDr. Xiao Bin, M.D., Ph.D., Postdoctoral FellowMs. Ong Ruyin, B.Sc., Senior Research Assistant
Several neurological disorders are amenable to neurorestorative therapies via stem cell transplantation. Importantly, the advent of the induced pluripotent stem cell (iPSC) technology heralded in a new era that looks set to revolutionize not only regenerative medicine, but also the way we study disease pathogenesis. Being the national neuroscience specialty hospital, NNI is uniquely positioned to take advantage of this technology. Notably, Dr. Tan EK has started the cellular transplantation programme in 1997 with the help of Dr. Olle Lindvall and his team in Lund, Sweden that led to actual fetal mesencephalic transplantation in humans. Dr. Lim KL was part of the NRF-CRP team (2009-2014) that evaluated the potential of iPSCs for neurological disorders and CNS repair. Our platform here represents an integrated regenerative medicine strategy that includes an efficient approach towards deriving patient-specific iPSCs (in a viral-free, feeder-free and xeno-free manner – Lu et al., Biomaterials 35:2816-26), a repository of iPSC for a range of neurological disorders, genome editing tools to correct genetic defects, bioengineering/bioprocessing tools for optimizing the differentiation of these cells into their preferred neuronal fate, and the evaluation of iPSC-derived neurons in transplanted preclinical models.
Professor Ng Huck Hui, Executive Director, Genome Institute of SingaporeProfessor Balazs Gulyas, LKC School of Medicine, Nanyang Technological UniversityDr. Steve Oh, Bioprocessing Technology Institute, A*STARDr. Jonathan Lo, Institute of Molecular and Cell Biology, A*STAR
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