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Calcium Signalling Laboratory

LIAO PING, MD, Ph.D.

Assistant Director, Basic and Translational Research, Research Department
Ph.D. National University of Singapore, 2001
Bachelor of Medicine, Master of Surgery (Neurosurgery),
West China University of Medical Sciences, Sichuan, China, 1996
Principal Investigator and Head, Calcium Signalling Laboratory
Adjunct Assistant Professor, Duke-NUS Graduate Medical School
Joint Assistant Professor, Singapore Institute of Technology

Contact Information

Calcium Signalling Laboratory, Level 6, Lab 6
National Neuroscience Institute
11 Jalan Tan Tock Seng, Singapore 308433
Tel: (65) 6357 7611 (Office) / (65) 6357 7615 (Laboratory)
Fax:(65) 6256 9178
Email: ping_liao@nni.com.sg

The Team

  • Dr Chen Bo
  • Dr Charlene Priscilla Poore
  • Ms Low See Wee (Lab Manager)
  • Ms Gao Yahui
  • Dr Wei Shunhui
  • Mr Byorn Tan (Medical Student)

NNI Calcium Signalling Laboratory.jpg

Overview

Cellular ionic homoeostasis is a highly regulated dynamic state of equilibrium of ions between intracellular and extracellular space. The concentration gradient of ions such as calcium, sodium, and potassium between intracellular and extracellular fluid plays a critical role in brain functions such as firing the action potential in neurons. In diseases of central nervous system such as stroke and head injury, disruption of ionic homoeostasis worsens acute tissue damage. The research in our lab focuses on the correction of ionic imbalance following a stroke, head injury and other central nervous system diseases. We expect novel therapies developed from our research to benefit patients.

Stroke is a leading cause of death and disability worldwide. This medical emergency occurs when blood flow to an area of the brain is cut off. There are two types of stroke, ischemic and hemorrhagic. About 80 percent of strokes are the ischaemic stroke, caused by the blockage of a cerebral blood vessel. The goals of treatment of acute ischemic stroke are to restore blood flow. Currently, the only FDA-approved treatment for ischemic strokes is tissue plasminogen activator which must be given to eligible patients within a short time window (<4.5 hours after stroke onset). Recanalization beyond this time window may generate severe side effects such as malignant oedema and haemorrhage due to vascular injury. Our lab aims to develop novel treatments that could extend current time window for reperfusion therapy by protecting vasculature.

As time is critical for stroke treatment, recognising the signs of a stroke can save a life. Use the letters in "fast" to spot stroke signs and know when to call 995 in Singapore: Face drooping, Arm weakness, Speech difficulty, Time to call 995.

Selected Publications (* joint first author, † corresponding author)

  1. Wang J, Li G, Yu D, Wong YP, Yong TF, Liang MC, Liao P, Foo R, Hoppe UC, Soong TW. Characterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure. Channels (Austin). 2017 Sep 26 [Epub ahead of print]
  2. Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu Z, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S, Soong TW. Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295.
  3. Hu Z, Wang JW, Yu D, Soon JL, de Kleijn DP, Foo R, Liao P, Colecraft HM, Soong TW. Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy. Sci Rep. 2016 Oct 12;6:35247.
  4. Qiu L, Ng G, Tan EK, Liao P†, Kandiah N†, Zeng L†. Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer's disease mice. Sci Rep. 2016 Apr 6;6:23964.
  5. Sun ZJ*, Ng KH*, Liao P*, Zhang Y, Ng JL, Liu ID, Tan PH, Chong SS, Chan YH, Liu J, Davila S, Heng CK, Jordan SC, Soong TW, Yap HK. Genetic Interactions Between TRPC6 and NPHS1 Variants Affect Posttransplant Risk of Recurrent Focal Segmental Glomerulosclerosis. Am J Transplant. 2015 Dec;15(12):3229-38.
    A commentary on this work was published in Nat Rev Nephrol: Edwards JK. Glomerular disease: TRPC6 and NPHS1 mediate FSGS risk. 2015 Sep; 11(9):505
  6. Liao P†, Yu D, Hu Z, Liang MC, Wang JJ, Yu CY, Ng G, Yong TF, Soon JL, Chua YL, Soong TW†. Alternative splicing generates a novel truncated Cav1.2 channel in neonatal rat heart. J Biol Chem. 2015 Apr 3;290(14):9262-72.
  7. Zhang E, Liao P†. Brain transient receptor potential channels and stroke. J Neurosci Res. 2015 Aug;93(8):1165-83.
    Featured article as an Editor’s choice for the August issue of the Journal of Neuroscience Research.
  8. Damodaran T, Hassan Z, Navaratnam V, Muzaimi M, Ng G, Müller CP, Liao P, Dringenberg HC. Time course of motor and cognitive functions after chronic cerebral ischemia in rats. Behav Brain Res.
     2014 Dec 15;275:252-8.
  9. Sharma P, Liao P. Calcium ion Influx in Microglial Cells: Physiological and Therapeutic Significance.
    J Neurosci Res. 2014 Apr;92(4):409-23.
  10. Loh KP, Ng G, Yu CY, Fhu CK, Yu D, Vennekens R, Nilius B, Soong TW, Liao P†. TRPM4 inhibition promotes angiogenesis after ischemic stroke. European Journal of Physiology (Pflugers Arch).
     2014 Mar;466(3):563-76.
  11. Yu CY, Ng G, Liao P†. Therapeutic Antibodies in Stroke. Transl Stroke Res. 2013;4:477-483.
  12. Papanayotou C*, De Almeida I*, Liao P*, Oliveira NM, Lu SQ, Kougioumtzidou E, Zhu L, Shaw A, Sheng G, Streit A, Yu D, Wah Soong T, Stern CD. Calfacilitin is a calcium channel modulator essential for initiation of neural plate development. Nat Commun. 2013;4:1837.
  13. Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW. Splice Variant Specific Modulation of CaV1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction. Circ Res. 2011 Nov 11;109(11):1250-8.
  14. Zhang HY*, Liao P*, Yu D, Soong TW. Alternative splicing of Cav1.2 channels determines the diltiazem sensitivity between cardiac and smooth muscle. British Journal of Pharmacology.
     2010 Aug;160(7):1631-40.
  15. Liao P†, Soong TW. Cav1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. European Journal of Physiology (Pflugers Arch). 2010 Jul;460(2):353-9.
    This paper is one of the most frequently downloaded articles of this journal in 2010.
  16. Liao P, Li G, Yu D, Yong TF, Wang J, Soong TW. Molecular alteration of Cav1.2 calcium channel in chronic myocardial infarction. European Journal of Physiology (Pflugers Arch). 2009 Aug;458(4):701-11.
  17. Liao P, Zhang HY, Soong TW. Alternative splicing of voltage-gated calcium channels: from molecular biology to disease. European Journal of Physiology (Pflugers Arch). 2009 Jul;458(3):481-7.
  18. Tao J, Hildebrand ME, Liao P, Liang MC, Tan G, Li S, Snutch TP, Soong TW. Activation of corticotropin-releasing factor receptor 1 selectively inhibits Cav3.2 T-type calcium channels. Mol Pharmacol. 2008 Jun;73(6):1596-609.
  19. Tang ZZ, Liao P, Li G, Jiang FL, Yu D, Hong X, Yong TF, Tan G, Lu S, Wang J, Soong TW. Differential Splicing Patterns of L-Type Calcium Channel Cav1.2 Subunit in Hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. Biochim Biophys Acta.-MOL CELL RES. 2008 Jan;1783(1):118-30.
  20. Liao P, Yu D, Li G, Yong TF, Soon JL, Chua YL, Soong TW. A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine. J Biol Chem. 2007 Nov 30;282(48):35133-42.
  21. Shen Y, Yu D, Hiel H, Liao P, Yue DT, Fuchs PA, Soong TW. Alternative splicing of the Cav1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells. J Neurosci. 2006 Oct 18;26(42):10690-9.
  22. Liao P, Yong TF, Liang MC, Yue DT, Soong TW. Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles. Cardiovasc Res. 2005 Nov 1;68(2):197-203.
  23. Liao P, Yu D, Lu S, Tang ZZ, Liang MC, Zeng S, Lin W, Soong TW. Smooth muscle selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels. J Biol Chem. 2004 Nov 26;279(48):50329-35.

Achievements of Students

  1. Lee Rui Zhi (Duke-NUS Medical School): Best Poster Presentation Award, Research Day, Duke-NUS Medical School, 2017
  2. Quek Hui Lin Jamie and Eong Rui Xuan (Ngee Ann Polytechnic, 2014): First Prize (Distinction Award), The Young Scientists' Symposium; Polytechnic, 2014): Winning Team, Polytechnic Student Research Programme.
  3. Byorn Tan (NUS High School of Mathematics and Science, 2013): Second Award, Taiwan International Science Fair.
  4. Jin Chentian (Raffles Institution, 2012): Silver Medal, Singapore Science and Engineering Fair; Second Prize, A*STAR Talent Search.