Murni Tio, Ph.D.Associate Research Scientist, Neuroscience Research LaboratoryAdjunct Assistant Professor, Duke-NUS Graduate Medical School
Neuroscience Research LaboratoryNational Neuroscience Institute - SGH Campus20 College Road, The Academia, Level 9 (Discovery Tower)Singapore 169856Tel: (65) 6576 7831 (Office) Email: email@example.com
In our laboratory, the fruit flies Drosophila melanogaster is used as an in vivo model organism to study movement disorders and neurodegenerative diseases (such as Parkinson's disease, essential tremor, etc.). We are particularly interested in understanding the mechanistic pathways involved in the pathogenesis of these diseases. In addition, we are also investigating processes of neuronal development/differentiation and how perturbation of it can lead to neurodegeneration. Among the approaches that we are using are human genetic analysis (in collaboration with Dr. E K Tan at NNI/SGH/Duke-NUS and Dr. Zhao Yi at DCR), the powerful genetics of Drosophila, transcriptome-translatome analysis (in collaboration with Dr. Guo Hui Li at A-Star) and searches for drugs. Due to high degree of conservation of genes, molecular/signalling pathways as well as physiological processes between human and flies, we believe that our research will lead to the discovery of causative aberrant mechanisms in human movement disorders and neurodegenerative diseases. We hope to apply this knowledge for preventive measures (bio-marker for detection of disease at early stages) as well as for treatment (through application of drugs currently used in clinics and development of new pharmacological drugs).
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