LIAO PING, MD, Ph.D.
Assistant Director, Basic and Translational Research, Research DepartmentPrincipal Investigator and Head, Calcium Signalling LaboratoryAssociate Professor (0.4FTE), Singapore Institute of TechnologyAssociate Professor (Track IIA-research), Duke-NUS Graduate Medical SchoolPh.D. National University of Singapore, 2001Bachelor of Medicine, Master of Surgery (Neurosurgery)West China University of Medical Sciences, Sichuan, China, 1996
Calcium Signalling Laboratory, Level 6, Lab 6National Neuroscience Institute11 Jalan Tan Tock Seng, Singapore 308433 Tel: (65) 6357 7611 (Office) / (65) 6357 7615 (Laboratory) Fax:(65) 6256 9178 Email: firstname.lastname@example.org
Cellular ionic homoeostasis is a highly regulated dynamic state of equilibrium of ions between intracellular and extracellular space. The concentration gradient of ions such as calcium, sodium, and potassium between intracellular and extracellular fluid plays a critical role in brain functions such as firing the action potential in neurons. In diseases of central nervous system such as stroke and head injury, disruption of ionic homoeostasis worsens acute tissue damage. The research in our lab focuses on the correction of ionic imbalance following a stroke, head injury and other central nervous system diseases. We expect novel therapies developed from our research to benefit patients.
Stroke is a leading cause of death and disability worldwide. This medical emergency occurs when blood flow to an area of the brain is cut off. There are two types of stroke, ischemic and hemorrhagic. About 80 percent of strokes are the ischaemic stroke, caused by the blockage of a cerebral blood vessel. The goals of treatment of acute ischemic stroke are to restore blood flow. Currently, the only FDA-approved treatment for ischemic strokes is tissue plasminogen activator which must be given to eligible patients within a short time window (<4.5 hours after stroke onset). Recanalization beyond this time window may generate severe side effects such as malignant oedema and haemorrhage due to vascular injury. Our lab aims to develop novel treatments that could extend current time window for reperfusion therapy by protecting vasculature.
As time is critical for stroke treatment, recognising the signs of a stroke can save a life. Use the letters in "fast" to spot stroke signs and know when to call 995 in Singapore: Face drooping, Arm weakness, Speech difficulty, Time to call 995.
Selected Publications (* joint first author, † corresponding author)
Achievements of Students
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