Clin Prof Louis Tan Chew Seng

Prof Louis Tan is a Senior Consultant Neurologist, Research Director, and Director of Clinical Programmes at the National Neuroscience Institute, Singapore.  He is also Academic Vice Chair (Research), Academic Clinical Program for Neuroscience, SingHealth-NUS Academic Medical Centre; Co-Director of the National Neuroscience Research Institute; and a Clinical Professor at Duke-NUS Graduate Medical School, Singapore.

He is the Chair of the Publications Oversight Committee of the International Parkinson and Movement Disorder Society and previously served as its Treasurer, Chair of the Education committee, Chair of the Asian-Oceanian Section of the Society, and a member of the International Executive Committee. 

Upon graduating from the National University of Singapore and completing his neurology training at Tan Tock Seng Hospital, he underwent a movement disorders fellowship at the Parkinson’s Institute in Sunnyvale, California. 

His areas of specialty and research interests are Parkinson’s disease and movement disorders. He is also interested in the interested in the epidemiology, clinical studies and clinical trials in Parkinson’s disease and other movement disorders.

• Specialist Accreditation in Neurology, Ministry of Health, Singapore, 2000
• Member of Royal College of Physicians (MRCP, United Kingdom), 1995
• ​MBBS National University of Singapore, 1990

• ​Senior Consultant, Department of Neurology, National Neuroscience Institute
• Director, Research, National Neuroscience Institute
  
• Academic Vice Chair, Research, Neuroscience Academic Clinical Programme
• Co-Director, National Neuroscience Research Institute (NNRIS) 
• Director NNI Tissue Bank, Chair of NNI Tissue bank steering committee 
• Director, Clinical Programmes, National Neuroscience Institute
• Clinical Professor, SingHealthDuke-NUS Neuroscience Academic Clinical Programme, Singapore
• Adjunct Associate Professor, Lee Kong Chian School of Medicine – NTU
• Clinical Senior Lecturer, Yong Loo Lin School of Medicine – NUS
• Co-Chair, Brain Bank Singapore Executive Committee
• President, Parkinson Society Singapore

• 2025 Philip Thompson Lectureship Award at the 9th International Asian and Oceanian Parkinson's disease and Movement Disorders Congress
• Duke-NUS Medical School 10-year service award, 2022
• Faculty Appreciation Award at the RiSE (Residency in SingHealth Excels) Awards 2022
• National Day Awards 2023 - Public Administration Medal, PPA (Bronze) 
• President's Science Award, Team Award, Singapore, 2018
• Distinguished Member Award.  The Japanese Society of Neurology. 57th Annual Meeting, 2016
• President’s Distinguished Service Award 2015, International Parkinson and Movement Disorders Society

• ​Epidemiology, clinical studies and clinical trials in Parkinson's disease and other movement disorders

• Theme PI for clinical studies in NMRC Open Fund Large Collaborative Grant – Singapore Parkinson’s disease Translational Clinical Programme, 2024-2029 - $25 Million.
• Theme PI for clinical studies in NMRC Open Fund Large Collaborative Grant – Singapore Parkinson’s disease Translational Clinical Programme, 2019-2024 - $25 Million. 
• Co-PI in National Medical Research Council – Translational clinical research grant for Parkinson’s disease (2014-2019 – $25 Million).

For a complete list of research publications, visit: ‪Louis C Tan‬ - ‪Google Scholar‬

• Santhanakrishnan A, Tan YJ, Saffari SE, Zhao Y, Ng EYL, Ng SYE, Chia NSY, Choi X, Heng D, Neo S, Xu Z, Tay KY, Au WL, Tan EK, Tan LCS, Ng ASL.  Carriers of Parkinson's disease-linked SNCA Rep1 variant have greater non-motor decline: a 4 year follow up study.  Aging (Albany NY). 2025 Feb 3.
• Chew EG, Liu Z, Li Z, Chung SJ, Lian MM, Tandiono M, Heng YJ, Ng EY, Tan LC, Chng WL, Tan TJ, Peh EK, Ho YS, Chen XY, Lim EY, Chang CH, Leong JJ, Peh TX, Chan LL, Chao Y, Au WL, Prakash KM, Lim JL, Tay YW, Mok V, Chan AY, Lin JJ, Jeon BS, Song K, Tham CC, Pang CP, Ahn J, Park KH, Wiggs JL, Aung T, Tan AH, Ahmad Annuar A, Makarious MB, Blauwendraat C, Nalls MA, Robak LA, Alcalay RN, Gan-Or Z, Reynolds R, Lim SY, Xia Y, Khor CC, Tan EK, Wang Z, Foo JN.  Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson's disease risk.  Nat Aging. 2024 Nov 21.
• Welton T, Hartono S, Lee W, Teh PY, Hou W, Chen RC, Chen C, Lim EW, Prakash KM, Tan LCS, Tan EK, Chan LL.  Classification of Parkinson's disease by deep learning on midbrain MRI.   Front Aging Neurosci. 2024 Aug 20;16:1425095. 
• Cai YZ, Zheng Y, Li W, Saffari SE, Ng HL, Zhan A, Xu Z, Tay KY, Au WL, Ng WH, Tan LCS, Wan KR, Neo S.  Long-term outcomes of subthalamic nucleus deep brain stimulation for Parkinson's disease in Singapore.  Ann Acad Med Singap. 2024 Aug 20;53(8):481-489. 
• Mehta A, Ng SYE, Neo SXM, Chia NSY, Saffari ES, Shivashanmugam T, Choi X, Heng DL, Xu ZY, Tay KY, Au WL, Tan EK, Tan LCS.  Assessment of social isolation and changes in Parkinson's disease symptoms during the COVID-19 pandemic: A longitudinal study.  Clin Park Relat Disord. 2024 Dec 9;12:100293. 
• Mohammadi R, Ng SYE, Tan JY, Ng ASL, Deng X, Choi X, Heng DL, Neo S, Xu Z, Tay KY, Au WL, Tan EK, Tan LCS, Steyerberg EW, Greene W, Saffari SE.  Machine Learning for Early Detection of Cognitive Decline in Parkinson's Disease Using Multimodal Biomarker and Clinical Data.  Biomedicines. 2024 Dec 3;12(12):2758. 
• Deng X, Saffari SE, Xiao B, Ng SYE, Chia N, Choi X, Heng DL, Xu Z, Tay KY, Au WL, Tan EK, Tan LC.  Disease progression in Parkinson's disease patients with mild cognitive impairment: 5-year longitudinal study from the early Parkinson's disease longitudinal Singapore (PALS) cohort.  Aging (Albany NY). 2024 Aug 12;16(15):11491-11500.
• Evans TE, Vilor-Tejedor N, Operto G, Falcon C, Hofman A, Ibáñez A, Seshadari S, Tan LC, Weiner M, Alladi S, Anazodo U, Gispert Lopez JD; ; Alzheimer’s Disease Neuroimaging Initiative; Australian Imaging Biomarkers and Lifestyle flagship study of ageing; Adams HHH.  Structural brain differences in the Alzheimer's disease continuum: Insights into the heterogeneity from a large multi-site neuroimaging consortium.  Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jul 29:S2451-9022(24)00207-6.Welton T, Teo TWJ, Chan LL, Tan EK, Tan LCS.  Parkinson's Disease Risk Variant rs9638616 is Non-Specifically Associated with Altered Brain Structure and Function.  J Parkinsons Dis. 2024;14(4):713-724
• Mehta A, Naheed D, Tan LCS, Neo S.  Paradoxical Gait Response to Levodopa in Parkin-Gene-Related Early-Onset Parkinson's Disease: Dopa Worsening Dystonia.  Mov Disord Clin Pract. 2024 May;11(5):580-581.
• Zheng Y, Wei L, Ang SYL, Ng HL, Au WL, Tay KY, Xu Z, Ng WH, Tan LCS, Neo SX, Wan KR.  Outcomes after deep brain stimulation for elderly versus non-elderly patients with Parkinson's disease.  Clin Neurol Neurosurg. 2024 Jul;242:108319.
• Deng X, Saffari SE, Xiao B, Ng SYE, Chia N, Choi X, Heng DL, Ng E, Xu Z, Tay KY, Au WL, Tan EK, Tan LCS.  Disease Progression of Data-Driven Subtypes of Parkinson's Disease: 5-Year Longitudinal Study from the Early Parkinson's Disease Longitudinal Singapore (PALS) Cohort.  J Parkinsons Dis. 2024;14(5):1051-1059.
• Cardoso F, Goetz CG, Mestre TA, Sampaio C, Adler CH, Berg D, Bloem BR, Burn DJ, Fitts MS, Gasser T, Klein C, de Tijssen MAJ, Lang AE, Lim SY, Litvan I, Meissner WG, Mollenhauer B, Okubadejo N, Okun MS, Postuma RB, Svenningsson P, Tan LCS, Tsunemi T, Wahlstrom-Helgren S, Gershanik OS, Fung VSC, Trenkwalder C.  A Statement of the MDS on Biological Definition, Staging, and Classification of Parkinson's Disease.  Mov Disord. 2024 Feb;39(2):259-266.