Ivan NG
MBBS, FRCSE, FRCS (Surgical Neurology)
Consultant
Dept of Neurosurgeon (Skull Base & Neurovascular)
Head, Section of Neuro Trauma & Neurovascular Surgery
Co-Director, Neurocritical Care Unit
Prinicipal Investigator
Acute Brain Injury Research Lab
11 Jalan Tan Tock Seng
Singapore 308433
Tel: (65) 6357 7196
Fax:(65) 6357 7137
Email: ivan_ng@nni.com.sg

RESEARCH AREAS

• Acute Brain Injury Research (Clinical): Head Injury, Skull base, Neuro-vascular, Neurointensive Care monitoring, Clinical and Academic trials
• Acute Brain Injury Research (Laboratory): MCAO models, Fluid Percussion models, Immunohistochemistry, Apoptosis, Blood Brain Barrier, DNA Vaccine, rt-PCR, HPLC, Neurocritical Care IT development

BIOGRAPHY

• Born 14 May 1966, SIngaporean, F.R.C.S. (Surgical Neurology)

AWARDS

• NORMAN DOTT MEDAL- AWARDED BY THE INTERCOLLEGIATE EXAMINATIONS BOARD UNITED KINGDOM IN NEUROSURGERY 2000 - FOR THE MOST OUTSTANDING PERFORMANCE AT THE INTERCOLLEGIATE SPECIALTY EXAM IN NEUROSURGERY FOR THE YEAR 2000
• HMDP SCHOLARSHIP IN NEUROSURGERY 1998 to 2000 - TO THE UNIVERSITY OF CAMBRIDGE, UK
• DERMATOLOGY BOOK PRIZE 1990 AWARDED BY THE DERMATOLOGICAL SOCIETY OF S'PORE (UNDERGRADUATE)
• THIRD PROZE, FREE PAPER COMPETITION - 9^TH INTERNATIONAL CONGRESS OF RECENT ADVANCES IN NEUROTRAUMATOLOGY
• ASEAN YOUNG NEUROSURGEON AWARD FOR BEST CLINICAL PAPER ENTITLED "APOPTOSIS IN CEREBRAL CONTUSIONS"; Bangkok 8^TH ASEAN Congress of Neurological Surgery 1999
• YOUNG INVESTIGATORS AWARD 32^ND SINGAPORE - MALAYSIA CONGRESS 1998 FOR BEST CLINICAL PAPER PRESENTED ENTITLED "APOPTOSIS IS INDUCED IN CLOSED HEAD INJURY IN HUMANS"
• BEST CLINICAL PAPER ENTITLED "PATIENTS WHO TALK AND DETERIORATE - A NEW LOOK AT AN OLD PROBLEM"; THIRD OVERALL at the International Conference on recent Advances in Neurotraumatology (ICRAN 2002 Bali August 2002)
• DOUGLAS MILLER AANS/CNS TRAVELLING FELLOWSHIP 2002 - AWARDED BY THE AMERICAN ASSOCIATION OF NEUROLOGICAL SURGEONS/CONGRESS OF NEUROLOGICAL SURGEONS
• TECHNOLOGY ENTERPRISE CHALLENGE AWARD 2003 - FOR MOST INNOVATIVE IDEA TOWARS THE IMPROVEMENT OF PUBLIC SERVICES IN SINGAPORE. BUILDING A NEURO-ICU OF THE FUTURE

RESEARCH PROJECTS

• Vascular Endothelial Growth Factor & Receptor Expression in Cerebral Arteriovenous Malformations (AVM) of the Brain
• Autoregulatioon disturbances in Acute Brain Injury
• Brain tissue Oxygenation in Acute Brain Injury
• In vivo Microdialysis - Aid to defining and optimisation of Cerebral Perfusion Pressure in Head Injury
• DNA vaccination with Neurite growth factors in an MCA occlusion model for rats-outcome assessment
• The synergistic action of PARP inhibitors and Anti-caspase in neuroprotection in rodents
• Correlation between coma state and hypocretin levels in Acute Brain Injury
• Towards Evidence Based Cost-effective Decision Making in Critical Care Medicine
• An Analysis of Spermine Expression in Cerebrospinal Fluid Using HPLC in Spontaneous Intracerebral Hemorrhage
• F7ICH-1371 - Randomised, Double-Blind, Placebo-Controlled, Multi-centre, Parallel Groups, Study to Evaluate the Efficacy and Safety of Activated Recombinant Factor VII (NovoSeven®) in Acute Intracerebral Haemorrhage. Sponsored by Novo Nordisk
• A Double Blind, Randomized, Placebo Controlled, Parallel Groups, Multicentre, Phase IIb/III Study to Assess the Efficacy and Safety of Intravenous NXY-059 in Acute Ischemic Stroke (SAINT-I) - Sponsored by AstraZeneca

SELECTED PUBLICATIONS

• Decision Analytic Approach to Severe Head Injury Management. David Hamanec, Tze-Yun Leong, Suman Sundaresh, Kim Leng Poh, Tseng Tsai Yeo, Ivan Ng, Thomas Lew. Proc AMIA Symp 1999:271-5
• Apoptosis occurs following cerebral contusions in humans. I Ng, TT Yeo, WY Tang, R Soong, PY Ng, DR.Smith. Neurosurgery 2000;46:949-956
• Prospective Study of Clinical and Radiological outcome after Anterior Cervical Discetomy. RJC Laing, I Ng, PJ Hutchinson. HM Br J Neurosurg 2001;15 (4):319-323
• Endoscopic Assisted Microneurosurgery for ruptured aneurysms. ECM Wang, I.Ng, PY Ng, PL Ong. J Clin Neuroscience 2003; Vol 10 (2):174-176
• Palmar Hyperhidrosis: Intraoperative Monitoring with Laser Doppler Blood Flow as a Guide for Success after Endoscopic Thoracic Sympathectomy. I.Ng, TT Yeo. Neurosurgery 2003;52:127-131
• Poly (adenosine diphosphate-ribose) polymerase expression in Traumatic Brain Injury. Ang BT, Tan WL, E Yap, I Ng. Journal of Neurosurgery 2003; 99:125-130
• Blood Brain Barrier Disruption following traumatic brain injury: Roles of Tight Junction proteins. I.Ng, E Yap, Tan WL, NY King. Annals Acad Med 2003;S63-S66 (Special Poster Presentation)
• Outcome of moderate and severe traumatic brain injury amongst the elderly in Singapore. BK Gan, JHG Lim, IHB Ng. Annals Acad Med 2004;33:63-67
• Spermine reduces infarction and neurological deficit following a rat model of MCA occlusion: a MRI study. Shirhan Md, M Moochala, PY Ng, J Lu, KC Ng, AL Teo, E Yap. I.Ng, P Hwang, T Lim, YY Sitoh, H Rumpel, R Jose, E Ling. Neuroscience 2004; 124:299-304
• Effects of Head Posture on Cerebral Hemodynamics: its influences on intracranial pressure, cerebral perfusion pressure and cerebral oxygenatio. Neurosuregery 2004; 54:593-598
• Patients who Talk and Deteriorate: A New Look at an Old Problem. JE Tan, I Ng, J Lim, Lee KK, HB Wong, TT Yeo. Annals Acad Med 2004; 33(4):489-493

TEAM MEMBERS

• Dr Seow Wan Tew
• Dr Yeo Tseng Tsai
• Dr Ernest Wang
• Dr Ng Wai Hoe
• Dr Jayant Thorat
• Dr Ang Beng Ti
• Ms Lee Kah Keow
• Ms Tan Wan Loo
• Mr Elgin Yap
• Ms Jill Wong
• Dr Zhu Xingbao
• Ms Jasmine Lee
• Mr Timothy Tan

COLLABORATORS

Local

• Prof E Ling  (NUS)
• Dr Xiao Zhi Cheng (SGH)
• Dr Feng Zhiwei (NNI)