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Carol Tang, Ph.D.
The Scripps Research Institute, 1998(Macromolecular and Cellular Structure and Chemistry)
Principal Investigator & Head
Neuro-Oncology Research Laboratory
National Neuroscience Institute
11 Jalan Tan Tock Seng
Singapore 308433
Tel: (65) 6357 7616 (Office)
(65) 6357 7634 (Lab)
Fax:(65) 6256 9178
Email: carol_tang@nni.com.sg
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THE LABORATORY: NEURO-ONCOLOGY
Our lab first started in mid-2005 and works in close conjunction with Christopher Beng-Ti Ang, Clinical Investigator at the Singapore Institute for Clinical Sciences, A*STAR. We are funded by competitive grants from the Biomedical Research Council and National Medical Research Council of Singapore. Currently, our combined teams have four graduate students enrolled at the National University of Singapore, one postdoctoral fellow, four research associates and an intern from the Nanyang Technological University.
Our initial efforts focused on understanding the cells that perpetuate glioblastoma multiforme (GBM), frequently called glioma-propagating or initiating cells. GBM is the most prevalent adult malignant glioma and survival is poor despite surgical and treatment advances. Our background findings in Stem Cells described the derivation of GBM-propagating cells from clinical material. We showed that these cells possessed stem cell-like expression, were multipotent and importantly, reformed orthotopic tumor xenografts that recapitulated the patients’ original tumor pathophysiology. Of note, histologically similar GBM tumors generated glioma-propagating cells with very different transcriptomic profiles. We believe this could explain the frequently observed inter-patient variability to treatment response. We have since illustrated that glioma-propagating cells could be subtyped into classes defined by signaling pathways such as TGFb, proneural expression etc.
Our lab’s interests lie in understanding mechanisms that regulate self-renewal of glioma-propagating cells, their resistance to chemotherapies, and tumor invasiveness. We have efforts in the topics of reactive oxygen species, sialylation, Wnt and related kinases. Some of these projects will be published in the near future and we look forward to updating this website.
We have excellent collaborators at the National Cancer Centre, Duke-NUS Graduate Medical School and the Yong Loo Lin School of Medicine.
AFFILIATIONS
1. Adjunct Assistant Professor, Cancer and Stem Cell Biology Program,
Duke-NUS Graduate Medical School (www.duke-nus.edu.sg)
2. Visiting Scientist, Division of Medical Sciences, National Cancer Centre (www.nccs.com.sg)
SELECTED PUBLICATION
1. Foong, C. S., Ng, F. S., Phong, M., Toh, T. B., Chong, Y. K., Tucker-Kellogg, G., Campbell, R. M., Ang, B. T., and Tang, C. Cryopreservation of cancer-initiating cells derived from glioblastoma. Front Biosci (Schol Ed) 3, 698 (2011).
2. Tay, S. P., Yeo, C. W., Chai, C., Chua, P. J., Tan, H. M., Ang, A. X., Yip, D. L., Sung, J. X., Tan, P. H., Bay, B. H., Wong, S. H., Tang, C., Tan, J. M., and Lim, K. L. Parkin enhances the expression of cyclin-dependent kinase 6 and negatively regulates the proliferation of breast cancer cells. J Biol Chem 285 (38), 29231 (2010).
3. Chong, Y. K., Toh, T. B., Zaiden, N., Poonepalli, A., Leong, S. H., Ong, C. E., Yu, Y., Tan, P. B., See, S. J., Ng, W. H., Ng, I., Hande, M. P., Kon, O. L., Ang, B. T., and Tang, C. Cryopreservation of neurospheres derived from human glioblastoma multiforme. Stem Cells 27 (1), 29 (2009).
4. Wang, C., Chang, K. C., Somers, G., Virshup, D., Ang, B. T., Tang, C., Yu, F., and Wang, H. Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells. Development 136 (13), 2287 (2009).
5. Zhao, H., Tang, C., Cui, K., Ang, B. T., and Wong, S. T. A screening platform for glioma growth and invasion using bioluminescence imaging. Laboratory investigation. J Neurosurg 111 (2), 238 (2009).
6. Chua, C., Zaiden, N., Chong, K. H., See, S. J., Wong, M. C., Ang, B. T., and Tang, C. Characterization of a side population of astrocytoma cells in response to temozolomide. J Neurosurg 109 (5), 856 (2008).
7. Tang, C., Ang, B. T., and Pervaiz, S. Cancer stem cell: target for anti-cancer therapy. FASEB J 21 (14), 3777 (2007).
8. Tang, C., Chua, C. L., and Ang, B. T. Insights into the cancer stem cell model of glioma tumorigenesis. Ann Acad Med Singapore 36 (5), 352 (2007)
THE TEAM
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