Louis Tan Chew Seng
MBBS, MRCP (UK), FAMS (Neurology)
FRCP (Edin)
Consultant
Department of Neurology
Parkinson's Disease & Movement Disorder
11 Jalan Tan Tock Seng
National Neuroscience Institute
Tel: (65) 6357 7177
Fax: (65) 6357 7137
Email: louis_tan@nni.com.sg

RESEARCH AREAS

• Parkinson's disease and Movement Disorders in areas of epidemiology, genetics, Paroxysmal Dyskineasias, clinical studies, clinical trials
  

BIOGRAPHY

Dr Louis Tan is a Consultant Neurologist at the National Neuroscience Institute in Singapore and a specialist in Parkinson's Disease and Movement Disorders. He trained with Dr Adrian Tan in Singapore and spent 2 years with the Parkinson's Institute in Sunnyvale, California, USA working with Drs William Langston, Daniel Togasaki and Caroline Tanner on a Movement Disorders Fellowship from 1999 to 2001. Dr Tan runs the Movement Disorders programme at the National Neuroscience Institute, Tan Tock Seng Campus. His research interests are in epidemiology, genetics and clinical studies in Parkinson's disease and movement disorders.

AWARDS

• Ministry of Health, FY98 HMDP Fellowship for Movement Disorders (12 months at The Parkinson's Institute, Sunnyvale, California)
• National Medical Research Council - Singapore Totalisator Board Medical Research Fellowship (12 months at the Parkinson's Institute, Sunnyvale, California)
• NHG Training Grant: 1^st Parkinson's Disease and Movement Disorders Symposium, SIngapore on 21^st and 22^nd February 2002
  

RESEARCH PROJECTS

• Prevalence and Incidence studies on Parkinson's disease and Essential Tremors in SIngapore
• Dietary and health factors for Parkinson's disease in the Singapore Chinese Health Study - a cohort study
• Quality of Life in patients with Parkinson's disease
• Genetics of Dystonia and Parkinson's disease
• Clinical trials
• Use of Botulinum Toxin for the treatment of migraine and tension headaches
  

SELECTED PUBLICATIONS

• Daniel M Togasaki, Louis Tan, Peter Protell, Donato DiMonte, Maryka Quik, J, William Langston
  
  Levodopa-induced dyskinesias in normal squrirrel monkeys.
  
  Annals of Neurology 2001;50 (2):254 - 7
  
  
• Matt Farrer, Piu Chan, Rong Chen, Louis Tan, Sarah Lincoln, Dena Hernandez, Lysia Forno, Katrina Gwinn-Hardy, Leonard Petrucelli, Jennifer Hussey, Andrew Singleton, CAroline Tanner, John Hardy, J. William Langston
  
  Lewy bodies and parkinsonism in families with parkin mutations
  
  Annals of Neurology 2001; 50:293 - 300
  
  
• Louis Tan, Peter Protell, J. William Langston, Daniel M Togasaki
  
  The hyperkinetic abnormal movements scale: a tool for evaluating levodopa-induced abnormal movements in squirrel monkeys
  
  Movement Disorders 2002; 17:902 - 909
  
  
• Louis Tan, Caroline Tanner, Rong Chen, Pui Chen, J William Langston
  
  Marked variation in clinical presentation and age of onset in a family with a heterozygous parkin mutation
  
  Movement Disorders 2003; 18(7): 758 - 763
  
  
• Louis CS Tan, Nan Luo, Mohammed Nazri, Shu Chuen Li, Julian Thumboo
  
  Validity and reliability of the PDQ-39 and PDQ-8 in English speaking patients in Singapore
  
  Parkinsonism and related disorders 2004; in press
  
  
• LCS Tan, N Venketasubramanian, CY Hong, S Sahadevan, JJ Chin, ES Krishnamoorthy, AKY Tan, SM Saw
  
  Prevalence of Parkinson's disease in Singapore: Chinese vs Malays vs Indians
  
  Neurology 2004; 62: 1999 - 2004
  

 TEAM MEMBERS

• Dr Au Wing Lok, Associated Consultant, Neurology
• Dr Dominic Jamora, Movement Disorders Fellow
• Ms Lau Puay Ngoh, PD Nurse Clinician
  

COLLABORATORS

Local

• Prof Lee Hin Peng and Dr Koh Woon Puay
  Department of Community, Occupational and Family Medicine
  National University of Singapore
  
• Prof Jean-Marc Burgunder
  Faculty of Medicine
  National University of Singapore
  

Overseas

• Prof Mimi Yu
  Department of Preventive Medicine
  University of Southern California