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Genomics

Tan Eng King

MBBS, MRCP (United Kingdom), FRCP (Edinburgh), FAMS (Neurology)

Director of Research
Senior Consultant, Department of Neurology
Professor and Deputy Director, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School
Co-Principal Investigator, Regenerative Medicine

Contact Information

National Neuroscience Institute
11 Jalan Tan Tock Seng, Singapore 308433
Tel: (65) 6321 4006

Overview

Our genomics platform provides support to decipher the genetics of neurological disorders such as movement disorders, stroke and Alzheimer's disease. We work with the Genome Institute of Singapore and external collaborators using contemporary genomics platforms with a particular focus on Asian specific genetic risk factors. Our current programme uses an Integrated GWAS and Whole Genome Exome and Sequencing Analysis approach to these neurological diseases so that we can further dissect and identify genetic risk factors and their functional significance in our patients.

The identification of novel genes and pathways that influence disease susceptibility holds promise for the identification of new drug targets. The ability to identify coding variants with high penetrance or large effects will also lead to an improvement in risk prediction allowing for early intervention and/or precision medicine.

Selected Publications

  1. Li H, et al. (2015) Patterns of linkage disequilibrium at PARK16 may explain variances in genetic association studies. Mov Disord. 2015 Mar 11 [Epub ahead of print]
  2. Foo JN, et al. (2014) Analysis of non-synonymous-coding variants of Parkinson's disease-related pathogenic and susceptibility genes in East Asian populations. Hum Mol Genet. 23(14):3891-7.
  3. Tan EK (2013) Genetics: Utility of next-generation sequencing in Ataxias. Nature Neurol. 9(11):614-5.
  4. Wu YR et al. (2013) Identification of a novel risk variant in the FUS gene in Essential tremor. Neurology. 81(6):541-4.
  5. Foo JN, et al. (2012) Whole-genome and whole-exome sequencing in neurological diseases. Nature Neurol. 8(9):508-17.
  6. Zhao Y, et al. (2011) LRRK2 variant associated with Alzheimer's disease. Neurobiol Aging. 32(11):1990-3.
  7. Reitz C, et al. (2011) Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Arch Neurol. 68(1):99-106.