Tan Eng King
MBBS, MRCP (United Kingdom), FRCP (Edinburgh), FAMS (Neurology)
Director of ResearchSenior Consultant, Department of NeurologyProfessor and Deputy Director, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical SchoolCo-Principal Investigator, Regenerative Medicine
National Neuroscience Institute11 Jalan Tan Tock Seng, Singapore 308433Tel: (65) 6321 4006
Our genomics platform provides support to decipher the genetics of neurological disorders such as movement disorders, stroke and Alzheimer's disease. We work with the Genome Institute of Singapore and external collaborators using contemporary genomics platforms with a particular focus on Asian specific genetic risk factors. Our current programme uses an Integrated GWAS and Whole Genome Exome and Sequencing Analysis approach to these neurological diseases so that we can further dissect and identify genetic risk factors and their functional significance in our patients.
The identification of novel genes and pathways that influence disease susceptibility holds promise for the identification of new drug targets. The ability to identify coding variants with high penetrance or large effects will also lead to an improvement in risk prediction allowing for early intervention and/or precision medicine.
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