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Publications

2019

  1. Association of Asymmetrical White Matter Hyperintensities and Apolipoprotein E4 on Cognitive Impairment. Low A, Ng KP, Chander RJ, Wong B, Kandiah N.J Alzheimers Dis. 2019 Jul 5. doi: 10.3233/JAD-190159
  2. Medial Temporal Atrophy in Amyloid-Negative Amnestic Type Dementia Is Associated with High Cerebral White Matter Hyperintensity. Wong BYX, Yong TT, Lim L, Tan JY, Ng ASL, Ting SKS, Hameed S, Ng KP, Zhou JH, Kandiah N. J Alzheimers Dis. 2019;70(1):99-106. doi: 10.3233/JAD-181261.
  3. Cerebrovascular Disease Is a Risk for Getting Lost Behavior in Prodromal Dementia. Yatawara C, Ng KP, Lim L, Chander R, Zhou J, Kandiah N. Am J Alzheimers Dis Other Demen. 2019 Aug;34(5):344-352. doi: 10.1177/1533317519852864. Epub 2019 May 29.
  4. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Wilson D, …, Kandiah N,….Werring DJ; Microbleeds International Collaborative Network. Lancet Neurol. 2019 Jul;18(7):653-665. doi: 10.1016/S1474-4422(19)30197-8. Epub 2019 May 23.
  5. Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Gallart-Palau X, Tan LM, Serra A, Gao Y, Ho HH, Richards AM, Kandiah N, Chen CP, Kalaria RN, Sze SK. Ageing Res Rev. 2019 May 19;53:100909. doi: 10.1016/j.arr.2019.100909.
  6. Construct validity of the Visual Cognitive Assessment Test (VCAT)-a cross-cultural language-neutral cognitive screening tool. Low A, Lim L, Lim L, Wong B, Silva E, Ng KP, Kandiah N. Int Psychogeriatr. 2019 May 21:1-9. doi: 10.1017/S1041610219000504
  7. Mechanisms Linking White Matter Lesions, Tract Integrity, and Depression in Alzheimer Disease. Yatawara C, Lee D, Ng KP, Chander R, Ng D, Ji F, Shim HY, Hilal S, Venketasubramanian N, Chen C, Zhou J, Kandiah N. Am J Geriatr Psychiatry. 2019 Apr 18. pii: S1064-7481(19)30337-9. doi: 10.1016/j.jagp.2019.04.004.
  8. Light-Induced Pupillary Responses in Alzheimer's Disease. Chougule PS, Najjar RP, Finkelstein MT, Kandiah N, Milea D. Front Neurol. 2019 Apr 12;10:360. doi: 10.3389/fneur.2019.00360. eCollection 2019. Review.
  9. DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface. Lock C, Kwok J, Kumar S, Ahmad-Annuar A, Narayanan V, Ng ASL, Tan YJ, Kandiah N, Tan EK, Czosnyka Z, Czosnyka M, Pickard JD, Keong NC. Front Med (Lausanne). 2019 Jan 10;5:357. doi: 10.3389/fmed.2018.00357. eCollection 2018.
  10. Hippocampal subfield atrophy of CA1 and subicular structures predict progression to dementia in idiopathic Parkinson's disease. Low A, Foo H, Yong TT, Tan LCS, Kandiah N. J Neurol Neurosurg Psychiatry. 2019 Jun;90(6):681-687. doi: 10.1136/jnnp-2018-319592. Epub 2019 Jan 25.
  11. Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: Expert consensus on the use of Ginkgo biloba extract, EGb 761®.Kandiah N, Ong PA, Yuda T, Ng LL, Mamun K, Merchant RA, Chen C, Dominguez J, Marasigan S, Ampil E, Nguyen VT, Yusoff S, Chan YF, Yong FM, Krairit O, Suthisisang C, Senanarong V, Ji Y, Thukral R, Ihl R. CNS Neurosci Ther. 2019 Feb; 25(2):288-298. doi: 10.1111/cns.13095.
  12. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum Therriault, J., Wang, S., Mathotaarachchi, S., Pascoal, T.A., Parent, M., Beaudry, T., Shin, M., Benedet, A.L., Kang, M.S., Ng, K.P. and Dansereau, C., 2019. Alzheimer’s Disease Neuroimaging Initiative. (2019). Molecular Neurobiology,  pp, 1-9.
  13. Aβ1-42 increases the expression of neural KATP subunits Kir6. 2/SUR1 via the NF-κB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons. Li, Y., Ba, M., Du, Y., Xia, C., Tan, S., Ng, K.P., and Ma, G., 2019. Human & experimental toxicology, p.0960327119833742.
  14. Predictors And Patterns of Cognitive Decline Differ between Mild Cognitive Impairment in Parkinson’s Disease (PD-MCI) And Alzheimer’s Disease (AD-MCI). Low, A., Yatawara, C., Yong, T.T., Chander, R.J., Ng, K.P., Kandiah, N., 2019. J Alzheimer’s Park Dement. 3(1):27.
  15. The combination of apolipoprotein E4, age and Alzheimer's Disease Assessment Scale - Cognitive Subscale improves the prediction of amyloid positron emission tomography status in clinically diagnosed mild cognitive impairment. Ba M, Ng KP, Gao X, Kong M, Guan L, … Alzheimer's Disease Neuroimaging Initiative. (2019). Eur J Neurol., 26 (5), pp. 733-e53.
  16. SNCA Rep1 promoter variability influences cognition in Parkinson's disease. Ng ASL, Tan YJ, Zhao Y, Saffari SE, Lu Z… Tan EK. (2019). Mov Disord.
  17. Plasma alpha-synuclein detected by single molecule array is increased in Parkinson’s Disease. ASL Ng, YJ Tan, Z Lu, E Ng, S Ng, N Chia, F Setiawan, Z Xu, KY Tay, KM Prakash, WL Au, EK Tan, LCS Tan. (2019). Ann Clin Transl Neurol., 6 (3), pp. 615-619.
  18. DTI Profiles for Rapid Description of Cohorts at the Clinical-Research Interface. Lock C, Kwok J, Kumar S, Ahmad-Annuar A, Narayanan V… Keong NC. (2019). Front Med (Lausanne), 10 (5), pp. 357.
  19. Higher serum triglyceride levels are associated with Parkinson’s disease mild cognitive impairment. XX Huang, S Ng, N Chia, S Acharyya, F Setiawan, Z Lu, YJ Tan, E Ng, MC Wen, ASL Ng, KY Tay, WL Au, EK Tan, LCS Tan. Under review in Movement Disorders journal
  20. Distinct disruptions of functional network topology in Alzheimer’s disease and Frontotemporal dementia. ASL Ng, Juan W, BL Choo, LJ Zhu, YM Loke, YJ Tan, S Hameed, SKS Ting, N Kandiah, Manuscript in preparation.

2018

  1. Serial position effects differ between Alzheimer's and vascular features in mild cognitive impairment. Chander RJ, Foo H, Yong T, Lim L, Tan J, Wen MC, Ng A, Hameed S, Ting S, Zhou J, Kandiah N. Aging (Albany NY). 2018 Dec 12;10(12):3866-3880. doi: 10.18632/aging.101678.
  2. Regional White Matter Hyperintensity Influences Grey Matter Atrophy in Mild Cognitive Impairment. Vipin A, Foo HJL, Lim JKW, Chander RJ, Yong TT, Ng ASL, Hameed S, Ting SKS, Zhou J, Kandiah N. J Alzheimers Dis. 2018;66(2):533-549. doi: 10.3233/JAD-180280.
  3. The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia.Ng KP, Chiew HJ, Lim L, Rosa-Neto P, Kandiah N, Gauthier S. Expert Rev Neurother. 2018 Nov;18(11):859-869. doi: 10.1080/14737175.2018.1532792. Epub 2018 Oct 10.
  4. Mapping the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory to the Health Utility Index Mark III. Cheung YB, Tan HX, Wang VW, Kandiah N, Luo N, Koh GCH, Wee HL.Qual Life Res. 2019 Jan;28(1):131-139. doi: 10.1007/s11136-018-1991-4. Epub 2018 Sep 1.
  5. Associations between lesions and domain-specific cognitive decline in poststroke dementia. Yatawara C, Ng KP, Chander R, Kandiah N. Neurology. 2018 Jul 3;91(1):e45-e54. doi: 10.1212/WNL.0000000000005734. Epub 2018 May 25.
  6. Targeted exome sequencing reveals homozygous TREM2 R47C mutation presenting with behavioral variant frontotemporal dementia without bone involvement. Ng ASL, Tan YJ, Yi Z, Tandiono M, Chew E, Dominguez J, Macas M, Ng E, Hameed S, Ting S, Tan EK, Foo JN, Kandiah N. Neurobiol Aging. 2018 Aug;68:160.e15-160.e19.
  7. A novel language-neutral Visual Cognitive Assessment Test (VCAT): validation in four Southeast Asian countries.Lim L, Ng TP, Ong AP, Tan MP, Cenina AR, Gao Q, Ng A, Kandiah N. Alzheimers Res Ther. 2018 Jan 22;10(1):6. doi: 10.1186/s13195-017-0333-z.
  8. Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease. Ng ASL, Ng EYL, Tan YJ, Kandiah N, Zhou J, Hameed S, Ting SKS, Tan EK. Neurobiol Aging. 2018 Apr;64:157.e7-157.e9. doi: 10.1016/j.neurobiolaging.2017.11.012. Epub 2017 Nov 27.
  9. Getting Lost Behavior in Patients with Mild Alzheimer's Disease: A Cognitive and Anatomical Model. Yatawara C, Lee DR, Lim L, Zhou J, Kandiah N.Front Med (Lausanne). 2017 Nov 16;4:201. doi: 10.3389/fmed.2017.00201. eCollection 2017.
  10. High Caregiver Burden in Young Onset Dementia: What Factors Need Attention? Lim L, Zhang A, Lim L, Choong TM, Silva E, Ng A, Kandiah N. J Alzheimers Dis. 2018;61(2):537-543. doi: 10.3233/JAD-170409.
  11. Interaction between APOE-ɛ4 and HMGB1 is associated with widespread cortical thinning in mild cognitive impairment. Foo H, Ng KP, Tan J, Lim L, Chander RJ, Yong TT, Kandiah N.J Neurol Neurosurg Psychiatry. 2018 Feb;89(2):225-226. doi: 10.1136/jnnp-2017-315869. Epub 2017 Jun 28. No abstract available.
  12. Neuropsychiatric symptoms in South-East Asian patients with mild cognitive impairment and dementia: prevalence, subtypes, and risk factors. Yatawara C, Hiu S, Tan L, Kandiah N. International Journal of Geriatric Psychiatry. 2018 Jan;33(1):122-130. doi: 10.1002/gps.4693. Epub 2017 Feb 27.
  13. Clinical Meaningfulness of Biomarker Endpoints in Alzheimer’s Disease Research. Ng, K.P., Pascoal, T.A., Li, X., Rosa-Neto, P. and Gauthier, S., 2018. In Biomarkers for Preclinical Alzheimer’s Disease (pp. 235-248). Humana Press, New York, NY.
  14. Characterizing biomarker features of cognitively normal individuals with ventriculomegaly. Li, X., Ba, M., Ng, K.P., Mathotaarachchi, S., Pascoal, T.A., … Alzheimer's Disease Neuroimaging Initiative, 2018. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 10, pp.12-21
  15. Cerebrospinal fluid phosphorylated tau, visinin-like protein-1, and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer's disease. Zhang H, Ng KP, Therriault J, Kang MS, Pascoal TA, Rosa-Neto P, Gauthier S; Alzheimer’s Disease Neuroimaging Initiative. Translational Neurodegeneration. 2018 Sep 10;7:23. doi: 10.1186/s40035-018-0127-7. eCollection 2018.
  16. The influence of language and culture on cognitive assessment tools in the diagnosis of early cognitive impairment and dementia. Ng KP, Chiew HJ, Lim L, Rosa-Neto P, Kandiah N, Gauthier S. Expert Review of Neurotherapeutics. 2018 Nov;18(11):859-869. doi: 10.1080/14737175.2018.1532792. Epub 2018 Oct 10.
  17. Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer's disease. Zhang H, Therriault J, Kang MS, Ng KP, Pascoal TA, Rosa-Neto P, Gauthier S; Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Research and Therapy. 2018 Aug 16;10(1):80. doi: 10.1186/s13195-018-0407-6.
  18. In vivo quantification of neurofibrillary tangles with [18F]MK-6240 Pascoal TA1,2, Shin M1, Kang MS1,2, Chamoun M2, Chartrand D2, Mathotaarachchi S1,2, Bennacef I3, Therriault J1, Ng KP1, Hopewell R, Bouhachi R, Hsiao HH, Benedet AL, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P. Alzheimers Research and Therapy. 2018 Jul 31;10(1):74. doi: 10.1186/s13195-018-0402-y.
  19. Impact of the biological definition of Alzheimer's disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology? Gauthier S, Zhang H, Ng KP, Pascoal TA, Rosa-Neto P. Translational Neurodegeneration. 2018 May 31;7:12. doi: 10.1186/s40035-018-0117-9. eCollection 2018.
  20. Associations between Lesions and Domain-Specific Cognitive Decline in Post Stroke Dementia. Neurology 2018. Yatawara C, Ng, K.P., Russell JC, Kandiah N. In press (IF: 8.32)
  21. Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment. Gauthier S, Ng KP, Pascoal TA, Zhang H, Rosa-Neto P.
    Journal of Alzheimer’s Disease. 2018;64(s1):S23-S31. doi: 10.3233/JAD-179924.
  22. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Ng, K.P., Pascoal, T.A., Mathotaarachchi, S., Chung, C.O., Benedet, A.L., Shin, M., Kang, M.S., Li, X., Ba, M., Kandiah, N. and Rosa-Neto, P., 2017. Neurology, pp.10-1212. (IF: 8.32)
  23. Anosognosia predicts default mode network hypometabolism and clinical progression to dementia. Therriault J, Ng KP, Pascoal TA, Mathotaarachchi S, Kang MS, Struyfs H, Shin M, Benedet AL, Walpola IC, Nair V, Gauthier S, Rosa-Neto P; Alzheimer's Disease Neuroimaging Initiative. Neurology. 2018 Mar 13;90(11):e932-e939. doi: 10.1212/WNL.0000000000005120. Epub 2018 Feb 14.
  24. Improving the Quality of Life in Persons with Dementia through a Pilot Study of a Creative Dance Movement Programme in an Asian Setting. Hameed S, Shah JM, Ting S, Gabriel C, Tay SY, et al. (2018). Int J Neurorehabilitation 5: 334.
  25. Phantom bedside intruder in Parkinson’s disease. Ting SKS, Chen C, Hameed S, et al. Neurology and Clinical Neuroscience. Published online 25 Nov 2018.
  26. Dyslexic Characteristics of Chinese-Speaking Semantic Variant of Primary Progressive Aphasia. Ting SKS, Foo H, Chia PS, Hameed S, Ng KP, Ng A, Kandiah N. J Neuropsychiatry Clin Neurosci. 2018 Winter;30(1):31-37. doi: 10.1176/appi.neuropsych.17040081. Epub 2017 Oct 24.
  27. Post-acupuncture headache: an unfortunate case of an inadvertent lumbar puncture. Narashimhalu K, Ting SKS, Lim SH.. Singapore Med J. 2018 Oct;59(10):557-558. doi: 10.11622/smedj.2018131.
  28. Ictal Asomatognosia With Illusory Limb Movement Secondary to Dominant Parietal Lobe Lesion. Ting SK, Yong KP, Hameed S. J Neuropsychiatry Clin Neurosci. 2015 Summer;27(3):e218-20. doi: 10.1176/appi.neuropsych.15010017.
  29. Higher serum triglyceride levels are associated with Parkinson's disease mild cognitive impairment. Huang X, Ng SY, Chia NS, Acharyya S, Setiawan F, Lu Z, Tan YJ, Ng E, Wen MC, Ng ASL, Tay KY, Au WL, Tan EK, Tan LC. Mov Disord. 2018 Dec;33(12):1970-1971. doi: 10.1002/mds.27521. Epub 2018 Oct 21.
  30. Case-control analysis of LRRK2 protective variants in Essential Tremor. Ng ASL, Ng EYL, Tan YJ, Prakash KM, Au WL, Tan LCS, Tan EK. Sci Rep. 2018 Mar 28;8(1):5346. doi: 10.1038/s41598-018-23711-w.

2017

  1. Ting SKS, Chia PS, Chan YH, Kwek KJH, Tan W, Hameed S, Tan EK. Characteristics of Chinese-English bilingual dyslexia in right occipito-temporal lesion. J Clin Neurosci. 2017 Aug 7. pii: S0967-5868(17)30849-4. doi:10.1016/j.jocn.2017.07.024. [Epub ahead of print] PubMed PMID: 28797604.
  2. Foo H, Ng KP, Tan YJ, Lim L, Cander RJ, Yong TT, Kandiah N. Interaction between APOE-ɛ4 and HMGB1 is associated with widespread cortical thinning in mild cognitive impairment. Journal of Neurology, Neurosurgery, and Psychiatry 2017. Epub available
  3. Ong M, Foo H, Chander RJ, Wen MC, Au WL, Sitoh YY, Tan L, Kandiah N. Influence of diabetes mellitus on longitudinal atrophy and cognition in Parkinson's disease. J Neurol Sci. 2017 Jun 15;377:122-126. doi: 10.1016/j.jns.2017.04.010. (IF: 2.474).
  4. Ting SKS, Earnest A, Li H, Hameed S, Chang HM, Chen CLH, Tan EK. B vitamins and cognition in subjects with small vessel disease: A Substudy of VITATOPS, a randomized, placebo-controlled trial. J Neurol Sci. 2017 Aug 15;379:124-126. doi: 10.1016/j.jns.2017.05.061. Epub 2017 May 30. PubMed PMID: 28716224.
  5. Kandiah N, Pai MC, Senanarong V, Looi I, Ampil E, Park KW, Karanam AK, Christopher S. Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's disease dementia. Clin Interv Aging. 2017 Apr 18;12:697-707. doi: 10.2147/CIA.S129145. (IF: 2.651).
  6. Tan YJ, Ng ASL, Vipin A, Lim JKW, Chander RJ, Ji F, Qiu Y, Ting SKS, Hameed S, Lee TS, Zeng L, Kandiah N, Zhou J. Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2017;58(2):413-423. doi:10.3233/JAD-161277. PubMed PMID: 28453482.
  7. Tan YJ, Ng ASL, Vipin A, Lim JKW, Chander RJ, Ji F, Qiu Y, Ting SKS, Hameed S, Lee TS, Zeng L, Kandiah N*, Zhou J*. Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2017;58(2):413-423. doi: 10.3233/JAD-161277. (IF: 3.920)
  8. Ng KP, Pascoal TA, Mathotaarachchi S, Chung CO, Benedet AL, Shin M, Kang MS, Li X, Ba M, Kandiah N, Rosa-Neto P, Gauthier S; Alzheimer's Disease Neuroimaging Initiative. Neuropsychiatric symptoms predict hypometabolism in preclinical Alzheimer disease. Neurology. 2017 May 9;88(19):1814-1821. doi: 10.1212/WNL.0000000000003916. (IF: 8.286).
  9. Yatawara C, Hiu S, Tan L, Kandiah N. Neuropsychiatric symptoms in South-East Asian patients with mild cognitive impairment and dementia: prevalence, subtypes, and risk factors. Int J Geriatr Psychiatry. 2017 Feb 27. doi: 10.1002/gps.4693. (IF: 2.419).
  10. Higher Peripheral TREM2 mRNA Levels Relate to Cognitive Deficits and Hippocampal Atrophy in Alzheimer's Disease and Amnestic Mild Cognitive Impairment Tan YJ, Ng ASL, Vipin A, Lim JKW, Chander RJ, … Zhou J. (2017). J Alzheimers Dis, 58 (2), pp. 413-423.