Profile
Dr Yeo is a Senior Consultant neurologist at the National Neuroscience Institute (NNI), Singapore, with clinical and research interests in neuroimmunological diseases. He currently runs a weekly neuroimmunology clinic at NNI, taking care of patients with Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD), Autoimmune Encephalitis and other immune-mediated CNS diseases.
In 2016, Dr Yeo was awarded the National Medical Research Council (NMRC) Singapore Research Fellowship Award to pursue a PhD at the University of Oxford under the supervision of Professors Daniel Anthony and Jacqueline Palace. His PhD focused on applying metabolomics in neuroimmunological diseases for biomarker discovery in human cohorts and investigating the metabolic perturbations associated with pathological processes in animal models of neuroinflammation. Dr Yeo was conferred his PhD in 2020.
Dr Yeo is actively involved in research on neuroimmunological diseases, and has lectured and presented at major regional and international MS conferences. His main research interest focuses on unravelling the molecular underpinnings in which environmental factors contribute to neuroinflammation, and in so doing, formulate potential interventions to alleviate neuroinflammation. In line with this research theme, he applied for and was awarded the NMRC Transition Award in 2021 to investigate the gut microbiome and metabolome and their relationship with systemic and neuroinflammation in Asian MS and NMOSD patients.
Dr Yeo holds a position of Assistant Professor at both Duke-NUS Medical School and Lee Kong Chian School of Medicine (NTU). He is also the Deputy Director of Brain Bank Singapore. Within NNI, he sits on several committees including the NNI Tissue Bank Tissue Release Committee and he is the Research Lead for both the Department of Neurology (NNI@TTSH campus) and the NNI Neuroimmunology-Neuroinflammation Programme. He is also involved in the clinical and research training of medical students, and provides continuous guidance of Neurology Senior Residents. Dr Yeo has received several awards for his clinical work, research and education.
Education
- PhD (DPhil Oxford), 2020
- MCI (NUS), 2017
- MMED Internal Medicine (NUS), 2012
- MRCP (UK), 2011
- MBBS (NUS), 2007
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Professional Appointments and Committee Memberships
- Senior Consultant, Department of Neurology, National Neuroscience Institute, Singapore
- Visiting Consultant, Department of Neurology, Changi General Hospital, Singapore
- Assistant Professor, Duke-NUS Medical School
- Assistant Professor, Lee Kong Chian School of Medicine, Nanyang Technological University
- Deputy Director, Brain Bank Singapore
- Clinical Lecturer (Yong Loo Lin School of Medicine, National University of Singapore)
- Research Lead, Department of Neurology (NNI@TTSH campus), 2021 to present
- Member, NNI Tissue Bank Tissue Release Committee, 2021 to present
- Deputy in charge, NNI Tissue Bank Neuroimmunology Collection, 2021 to present
- Research Lead, NNI Neuroimmunology-Neuroinflammation Programme, 2020 to present
- Editor, NNI Research Newsletter, 2020 to present
- Member, Committee for APN (advanced practitioner nurse) Competence, NNI, 2020 to present
- Member, FAMS (Neurology), 2016 to present
- Member, Peer Review Learning Quality Assurance Committee, NNI, 2016 to present
- Faculty, SingHealth Neurology Residency Program, 2015 to present
- Member, Clinical Neuroscience Society Singapore, 2012 to present
- Member, SingHealth Infection Control and Audit (SICA) Task Force, 2015 to 2016
- Member, SingHealth Infection Control and Prevention (SICP) Workgroup, 2015 to 2016
- Treasurer, Clinical Neuroscience Society Singapore, 2015 to 2016
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Awards
- NNI Service Quality Award, Gold Award (NNI, 2022)
- Singapore Health Quality Service Award, Gold Award (SingHealth, 2022)
- Singapore Health Quality Service Award, Silver Award (SingHealth, 2021)
- Transition Award (NMRC, 2021)
- SingHealth Duke-NUS Neuroscience ACP Research Paper of the Quarter (Jan – Jun 2020)
- Educational Award (MSVirtual, 2020)
- SingHealth Duke-NUS Neuroscience ACP Research Paper of the Quarter (Jul – Dec 2019)
- Long Service Award (10 years) (SingHealth, 2018)
- Educational Travel Award (ACTRIMS, 2019)
- Educational Travel Award (ECTRIMS Summer School, 2019)
- Travel Award (1st Nordic Metabolomics Conference, 2018)
- Research Training Fellowship Award, Overseas PhD (NMRC, 2016)
- Outstanding Tutor Award (Yong Loo Lin School of Medicine, NUS, 2016)
- MCI Research Scholarship Award (NMRC, 2015)
- Best Registrar Award (SingHealth, 2015)
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Research Interests
- Neuroimmunology
- Neuroinflammation
- Biomarkers
- Multi-omics
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Publications
- Yeo T, Bayuangga H, Augusto-Oliveira M, Sealey M, Claridge TDW, Tanner R, Leppert D, Palace J, Kuhle J, Probert F, Anthony DC. Metabolomics detects clinically silent neuroinflammatory lesions earlier than neurofilament-light chain in a focal multiple sclerosis animal model. J Neuroinflammation 2022;19, 252.
- Yeo T, Probert F, Sealey M, Saldana L, Geraldes R, Höeckner S, Schiffer E, Claridge TDW, Leppert D, DeLuca G, Kuhle J, Palace J, Anthony DC. Objective biomarkers for clinical relapse in Multiple Sclerosis: A metabolomics approach. Brain Commun 2021;3(4):fcab240.
- Probert F*, Yeo T*, Zhou Y, Sealey M, Arora S, Palace J, Claridge TDW, Hillenbrand R, Oechtering J, Kuhle J, Leppert D, Anthony DC. Determination of CSF GFAP, CCN5, and vWF levels enhances the diagnostic accuracy of MS from non-MS patients with CSF oligoclonal bands. Front Immunol 2022;12:811351. (*joint first authors)
- Yeo T, Sealey M, Zhou Y, Saldana L, Loveless S, Claridge TDW, Robertson N, DeLuca G, Palace J, Anthony D, Probert F. A blood-based metabolomics test to distinguish relapsing-remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application. Sci Rep 2020;10:12381.
- Yeo T*, Probert F*, Jurynczyk M, Sealey M, Cavey A, Claridge TDW, Woodhall M, Waters P, Leite MI, Anthony DC, Palace J. Classifying the antibody-negative NMO syndromes: Clinical, imaging, and metabolomic modelling. Neurol Neuroimmunol Neuroinflamm. 2019 Oct 28;6(6):e626. (*joint first authors)
Refer to Google Scholar for full list of publications: https://scholar.google.com.sg/citations?user=BiAIDdEAAAAJ&hl=en
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Research Trials
As Principal Investigator:
- Neuroimmunology Longitudinal Singapore (NILONS) Study, Department of Neurology, NNI
- Deciphering the relationship between the gut microbiome and metabolome with systemic and neuroinflammation in Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder and related neuroimmunological disorders, Department of Neurology, NNI
- Longitudinal evaluation of immunogenic responses after COVID-19 vaccination in patients with Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder and related neuroinflammatory disorders, Department of Neurology, NNI
- Validity and reliability of the Fatigue Severity Scale in Multiple Sclerosis and Neuromyelitis Optica/Neuromyelitis Optica Spectrum Disorder population in Singapore (FAMNS), Department of Neurology, NNI
- Prevalence of Central Nervous System Autoantibodies in Cryptogenic Epilepsy and Insights into Immunotherapy Treatment Effect (PACE), Department of Neurology, NNI
- Validation of a Commercial Assay in the Detection of LGI1 and CASPR2 Antibodies, Department of Neurology, NNI
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