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Dr Tan Yee-Leng

Dr Tan Yee-Leng

​MBBS, MMed (Internal Medicine), MRCP (United Kingdom)

Senior Consultant

National Neuroscience Institute

Specialty: Neurology, Neurology

Clinical Interest: Epilepsy, General Neurology

Conditions Treated by this Doctor:

Clinical Appointments

  • Senior Consultant Department of Neurology National Neuroscience InstituteNational Neuroscience Institute


​Dr Tan Yee-Leng is a Senior Consultant with the Department of Neurology and the Head of Ambulatory Services at the National Neuroscience Institute. After obtaining her specialist accreditation in neurology from the Ministry of Health (Singapore), she pursued her subspecialty training in epilepsy and completed a 2-year fellowship at the Montreal Neurological Institute (Canada) and University of California, San Francisco.

Her clinical and research work focuses on the diagnosis and management of patients with epilepsy, including those who remain with refractory seizures. She is actively involved in both local and international project collaborations, which aim to develop advanced neurophysiology and imaging techniques as well as prediction tools for the optimisation of clinical care.


​Research Fellowship in epilepsy imaging (USCF), 2015-2016

Frederick Andermann Fellowship in Epileptology and EEG (MNI), 2014-2015

MMed (Internal Medicine), 2009

MRCP (United Kingdom), 2009

MBBS (National University of Singapore), 2005

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Neurology, National Neuroscience Institute
  • Head of Ambulatory Services, National Neuroscience Institute
  • Clinical Tutor, Yong Loo Lin School of Medicine
  • Adjunct Assistant Professor, Duke-NUS Medical School
  • Clinical Tutor, Facilitator, Lee Kong Chian School of Medicine
  • Member, Singapore Medical Association
  • Member, National Pharmacy and Therapeutics Committee, 2016 - Present
  • Member, Chronic Disease Management Programme (CDMP) clinical advisory committee, 2016 - Present


  • Special Recognition Award, Yong Loo Lin School of Medicine Education, 2017
  • National Neuroscience Institute, Silver Service Quality Award, 2016
  • Nurturing Clinician Scientist Award, 2016
  • Ministry of Health Training Scholarship (HMDP), 2013
  • SingHealth Best Registrar Award, 2013

Research Interests

  • Epilepsy
  • Brain imaging
  • EEG and source localisation
  • Computer aided diagnostics


  • Quantitative surface analysis of combined MRI and PET enhances detection of focal cortical dysplasias.
    Tan YL, Kim H, Lee S, Tihan T, Ver Hoef L, Mueller SG, Barkovich AJ, Xu D, Knowlton R. Neuroimage. 2017 Oct 30. pii: S1053-8119(17)30901-1. doi: 10.1016/j.neuroimage.2017.10.065. [Epub ahead of print]
  • Unsupervised Learning of Spatiotemporal Interictal Discharges in Focal Epilepsy. Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, Chang EF. Neurosurgery. 2017 Oct 10. doi: 10.1093/neuros/nyx480. [Epub ahead of print]
  • Psychogenic nonepileptic seizures in patients with surgically treated temporal lobe epilepsy: Presurgical and de novo postsurgical occurrence. González Otárula KA, Tan YL, Dubeau F, Correa JA, Chang E, Hall JA, Knowlton RC, Kobayashi E.  Epilepsy Behav. 2017 Oct;75:252-255. doi: 10.1016/j.yebeh.2017.08.015. Epub 2017 Sep 1.
  • MRI-negative temporal lobe epilepsy-What do we know? Muhlhofer W, Tan YL, Mueller SG, Knowlton R. Epilepsia. 2017 May;58(5):727-742. doi: 10.1111/epi.13699. Epub 2017 Mar 7. Review.
  • Pearls and Oy-sters: The chapeau de gendarme sign and other localizing gems in frontal lobe epilepsy. Tan YL, Muhlhofer W, Knowlton R. Neurology. 2016 Sep 6;87(10):e103-5. doi: 10.1212/WNL.0000000000003058. No abstract available.
  • Antiepileptic treatment for anti-NMDA receptor encephalitis: the need for video-EEG monitoring.  Tan YL, Tan K, Tan NC.'  Epileptic Disord. 2013 Dec;15(4):468. No abstract available.
  • Frontotemporal dementia in southeast Asia: a comparative study. Tan YL, Ng A, Kandiah N. Dement Geriatr Cogn Dis Extra. 2013 Jan;3(1):1-9. doi: 10.1159/000345780. Epub 2013 Jan 11.
  • Left ventricular fluid dynamics in heart failure: echocardiographic measurement and utilities of vortex formation time. Poh KK, Lee LC, Shen L, Chong E, Tan YL, Chai P, Yeo TC, Wood MJ. Eur Heart J Cardiovasc Imaging. 2012 May;13(5):385-93. doi: 10.1093/ejechocard/jer288. Epub 2011 Dec 16.
  • The impact of gender on the outcomes of invasive versus conservative management of patients with non-ST-segment elevation myocardial infarction. Lee LC, Poh KK, Tang TP, Tan YL, Tee HW, Tan HC. Ann Acad Med Singapore. 2010 Mar;39(3):168-72.

Research Trials