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Dr Low Yin Yee Sharon

Dr Low Yin Yee Sharon

MBBS, MRCS (Ed), MMed (Surgery), PhD, FRCS (Surgical Neurology), GDPM

Head of Service & Consultant

National Neuroscience Institute

Specialty: Neurosurgery, Surgery & Surgical Oncology

Sub-specialties: Paediatric Neurosurgery, Neuro-Oncology

Conditions Treated by this Doctor:
Brain cancer, Brain Tumours, Brain Tumours CN, Neuro-oncology, Paediatric Neurosurgery.

Clinical Appointments

  • Head of Service & Consultant Department of Neurosurgery National Neuroscience InstituteNational Neuroscience Institute
  • Head & Consultant Neurosurgical Service KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Consultant Paediatric Brain and Solid Tumour Programme KK Women's and Children's HospitalKK Women's and Children's Hospital
  • Consultant Neurosurgery Singapore General HospitalSingapore General Hospital
  • Consultant Division of Surgery & Surgical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore


Dr ​Sharon Low graduated with an MBBS from Monash University (Australia) and has completed her Advanced Surgical Training (Neurosurgery) at the National Neuroscience Institute (Singapore). Her personal interest is in neuro-oncology and other CNS-related neoplasms. This led to her embarking on a research PhD at the National University of Singapore (NUS).

In February 2015, she successfully defended her PhD thesis titled ‘Characterizing therapeutically resistant human glioblastoma cells’. This was followed by her completion of her FRCS (Surgical Neurology) exams in September 2015. She continues in pursuit of research interests centred around paediatric brain tumours and their oncogenic mechanisms.

She strongly believes in a holistic approach in the management of patients afflicted by difficult brain tumours, whereby there is a need to combine good neurosurgical techniques, in-depth molecular research, and more importantly for the patients and their families, psychosocial support for better disease management.


  • MBBS

Professional Appointments and Committee Memberships

  • Consultant, Department of Neurosurgery, National Neuroscience Institute
  • ​Head of Service and Consultant, Neurosurgical Services, KK Women's and Children's Hospital


Research Interests

  • ​Neuro-oncology
  • CNS-related neoplasms


  • Low S. 'Who is Responsible for this Patient?': A Case Study Analysis of Conflicting Interests between Patient, Family and Doctor in a Singaporean Context. Asian Bioethics Review 2011;3:261-71 JIF: 0.111
  • Low YY, Thomas J, Wan WK, Ng WH. Brain metastases as a cause of malignant cerebrospinal fluid ascites: case report and review of the literature. CNS Oncol 2012;1(1):29-37 JIF: 1.62
  • Low S. "Dying Well" in Singapore: Reflecting on Terminal Cancer Management. Asian Bioethics Review 2012;4:226-35 JIF: 0.111
  • Low SY, Ong CW, Hsueh PR, Tambyah PA, Yeo TT. Neisseria gonorrhoeae paravertebral abscess. J Neurosurg Spine 2012;17(1):93-7 JIF: 1.744
  • Low CY, Low YY, Lee KK, Chan SP, Ang BT. Post-traumatic hydrocephalus after ventricular shunt placement in a Singaporean neurosurgical unit. J Clin Neurosci 2013;20(6):867-72 JIF: 1.744
  • Low SY, Ho YK, Too HP, Yap CT, Ng WH. MicroRNA as potential modulators in chemoresistant high-grade gliomas. J Clin Neurosci 2014;21(3):395-400 JIF: 1.744, Times Cited: 24
  • Wan KR, King NK, Low SY, Sitoh YY, Lee HY, Wong CF, et al. Synchronous multicentric glioblastoma with PNET and O subtypes: Possible pathogenesis. Surg Neurol Int 2014;5:31 JIF: 0.995
  • Low S, Wan Tew S. The Child with a Brain Tumour: Vulnerability Perspectives from Neurosurgery. Asian Bioethics Review 2015;7:250-6 JIF: 0.111
  • Yeo JJ, Low SY, Seow WT, Low DC. Pediatric de novo cerebral AVM: report of two cases and review of literature. Childs Nerv Syst 2015;31(4):609-14 JIF: 1.284
  • Lim JX, King N, Low S, Ng WH. Serum procalcitonin is a marker for prediction of readmission from an intermediate care to an acute care hospital in neurosurgical patients. Surg Neurol Int 2015;6:144 JIF: 0.995
  • Chua FH, Low SY, Tham CK, Ding C, Wong CF, Nolan CP. Disseminated extracranial metastatic meningioma. J Clin Neurosci 2016;33:214-6 JIF: 1.744
  • Yeo JJ, Low YY, Putti TC, Koh KM. Adult intraventricular astroblastoma. Singapore Med J 2016;57(1):53-4 JIF: 1.060
  • Yan B, Kuick CH, Lim M, Yong MH, Lee CK, Low SYY, et al. Characterization of anaplastic lymphoma kinase-positive medulloblastomas. J Clin Neurosci 2016;23:120-2 JIF: 1.744
  • Sharon LY, Wai Hoe NG. 'Subarachnoid cyst' after evacuation of chronic subdural hematoma: Case report of an unusual postoperative morbidity. Asian J Neurosurg 2016;11(3):316
  • Lee L, Low S, Low D, Ng LP, Nolan C, Seow WT. Late pediatric ventriculoperitoneal shunt failures: a Singapore tertiary institution's experience. Neurosurg Focus 2016;41(5):E7 JIF: 2.158
  • Y. Chua J, Min Ling J, W.Q. Lian D, Yoke Chan M, C.Y. Low D, Low S. Altano-axial subluxation with torticollis secondary to Langerhans cell histocytosis. Interdisciplinary Neurosurgery 2017;10: 101-3 JIF: 0.24
  • Chua FHZ, Low DCY, Lian DWQ, Tew SW, Low SYY. Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. Childs Nerv Syst 2017;33(4):563-5 JIF: 1.284
  • Low SYY, Lian DWQ, Tang PH, Loh E, Seow WT, Low DCY. Concurrent paediatric medulloblastoma and Chiari I malformation with syringomyelia. Childs Nerv Syst 2017;33(6):881-3 JIF: 1.284
  • Qiu L, Tang YL, King NKK, Chuah KL, Lai SH, Lim KHC, Low YY. IDH1 mutant negative ganglioglioma progression to gliosarcoma. Interdisciplinary Neurosurgery 2017;9:41-4 JIF: 0.24
  • Chua FHZ, Thien A, Ng LP, Seow WT, Low DCY, Chang KTE, Lian DWQ, Loh E, Low SYY. Post-operative diffusion weighted imaging as a predictor of posterior fossa syndrome permanence in paediatric medulloblastoma. Childs Nerv Syst 2017;33(3):457-65 JIF: 1.284
  • Ang SY, Ng VW, Kumar SD, Low SY. Cryptococcosis mimicking lung carcinoma with brain metastases in an immunocompetent patient. J Clin Neurosci 2017;35:73-5 JIF: 1.744
  • Chua FHZ, Low DCY, Lian DWQ, Ng LP, Chang KTE, Loh E, Low SYY, et al. Medulloblastoma with tri-vergent melanocytic, myogenic and cartiligious elements. J Clin Neurosci 2017;41:100-3 JIF: 1.744
  • Chan SH, Chew W, Ishak NDB, Lim WK, Li S-T, Tan SH, Low SYY et al. Clinical relevance of screening checklists for detecting cancer predisposition syndromes in Asian childhood tumours. npj Genomic Medicine 2018;3(1):30 JIF: 3.710
  • Low SYY, Wei CM, Chang KTE, Huak CY, Ping NL, Tew SW, et al. Intra-operative cerebrospinal fluid sampling versus post-operative lumbar puncture for detection of leptomeningeal disease in malignant paediatric brain tumours. PLoS One 2018;13(5):e0196696 JIF: 2.859
  • Looi WS, Low DCY, Low SYY, Goh SH. Neonatal orbital swelling due to intracranial teratoma. Arch Dis Child Fetal Neonatal Ed 2018 JIF: 3.711
  • Low SYY, Soh SY, Chen MW, Ng LP, Low DCY, Seow WT. DTI fusion with conventional MR imaging in intra-operative MRI suite for paediatric brainstem glioma biopsy. Childs Nerv Syst 2018;34(1):19-21 JIF: 1.284
  • Yeo JJY, Chang KTE, Ng LP, Seow WT, Low DCY, Low SYY. Cystic Cavernoma of Fourth Ventricle in Pediatric Patient. World Neurosurg 2018;111:255-7 JIF: 1.628
  • Chen M, Low DCY, Low SYY, Muzumdar D, Seow WT. Management of brain abscesses: where are we now? Childs Nerv Syst 2018;34(10):1871-80 JIF: 1.284
  • Tan GI, Low DC, Ng LP, Seow WT, Low SY. Synchronous Chiari III Malformation and Polydactyly. World Neurosurg 2018;118:301-3 JIF: 1.628
  • Tan GIL, Merchant K, Tan EEK, Low DCY, Ng LP, Seow WT, Low SYY. A germline variant of TP53 in paediatric diffuse leptomeningeal glioneuronal tumour. Childs Nerv Syst 2019;35(6):1021-7 JIF: 1.284
  • Low SYY, Kuick CH, Seow WY, Bte Syed Sulaiman N, Chen H, Lian DWQ, et al. Primary paediatric epidural sarcomas: molecular exploration of three cases. BMC cancer 2019;19(1):182 JIF: 3.243
  • Low SYY, Iqbal J, Chang KTE, Koh RKM. Symptomatic radionecrosis of cerebral arteriovenous malformation post-stereotactic radiosurgery: Report of 2 cases. Interdisciplinary Neurosurgery 2019 JIF: 0.24
  • Low SYY, Ker JR, Ng LP, Seow WT, Low DCY. Thoracic epidural haematoma after spinal manipulation treatment. Childs Nerv Syst 2019;35(5):735-7 JIF: 1.284
  • Khalid MT, Chan D, Tan EEK, Seow WT, Ng LP, Low CY, Low SYY. Right middle cerebral artery infarct after minor head trauma in an infant: case report and literature review. International Journal of Pediatrics and Adolescent Medicine 2019 (manuscripted accepted, under production)
  • Primalani N, Quek T, Low CY, Low S. Spontaneous intracranial hypotension presenting as cervicogenic headache: case report and review of literature. World Neurosurg 2019 (manuscripted accepted, under production) JIF: 1.628
    Low S, Ng LP, Tan AJ, Low CY, Seow WT. The Seow Operative Score (SOS) as a decision-making adjunct for paediatric Chiari I Malformation: a preliminary study. Childs Nerv Syst 2019 (manuscripted accepted, under production) JIF: 1.284
  • Wan KR, Kirollos R, Lee HY, Low CY, Ng LP, Seow WT, Low SYY et al. Giant aneurysm arising from anomalous branch of the middle cerebral artery in a paediatric patient: case report and review of literature. World Neurosurg 2019 (manuscripted accepted, under production) JIF: 1.628

Research Trials