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Clin Asst Prof Lin Xuling

Clin Asst Prof Lin Xuling

MBBS, MRCP (United Kingdom)

Senior Consultant

National Neuroscience Institute

Specialty/Department: Neurology, Neurology

Clinical Interest: General Neurology, Neuro-Oncology

Conditions Treated by this Doctor:
General Neurology, Glioma.

Clinical Appointments

  • Senior Consultant Department of Neurology National Neuroscience InstituteNational Neuroscience Institute
  • Visiting Consultant Division of Medical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore
  • Assistant Director, Research (Research Platforms) Research (National Neuroscience Institute) National Neuroscience InstituteNational Neuroscience Institute

Profile

Clin Asst Prof Lin Xuling is a Neurologist, with a clinical interest in Neuro-Oncology and manages patients with Neurological conditions including brain tumours. She is also currently serving at theView More +

Education

  • MMED Internal Medicine (Singapore), 2011
  • MRCP (United Kingdom, 2010
  • MBBS National University of Singapore, 2007

Professional Appointments and Committee Memberships

  • Senior Consultant, Department of Neurology, National Neuroscience Institute, 2021 - Present
  • Director, Clinical, SingHealth Office of Regional Health
  • Assistant Director, Research (Research Platforms), National Neuroscience Institute, 2021 - Present
  • Consultant, Department of Neurology, National Neuroscience Institute, 2016 - 2021
  • Associate Consultant, Department of Neurology, National Neuroscience Institute, 2014 - 2016
  • Visiting Consultant, Medical Oncology, National Cancer Centre, 2017 - Present
  • Visiting Consultant, Medical Oncology, Tan Tock Seng Hospital
  • Programme Director, NNI Brain Tumours Clinical Programme, 2018 - Present
  • ​Clinical Assistant Professor, Duke-National University of Singapore
  • Clinical Lecturer, Yong Loo Lin School of Medicine
  • Clinical Teacher, Lee Kong Chian School of Medicine
  • Member, Personalised Medicine Clinical Genomics Work Group, Tan Tock Seng Hospital, 2017 - Present
  • Member, Cancer Service Line Development, National Cancer Centre, Singapore 2017 - Present
  • Fellow, Neuro-Oncology, Memorial Sloan Kettering Cancer Center, 2014 - 2016
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Awards

  • ​Best Registrar Award, SingHealth Residency, 2014
  • SingHealth HMDP Award, FY2014 Fellowship in Neuro-Oncology, 2014

Research Interests

  • ​Brain tumor clinical trials
  • Cancer genomics
  • Neuroimaging

Publications

  • X Lin, M Fleisher, M Rosenblum, O Lin, A Boire, S Briggs, Y Bensman, B Hurtado, L Shagabayeva, L DeAngelis, K Panageas, A Omuro, E Pentsova. Cerebrospinal Fluid Circulating Tumor Cells: A Novel Tool to Diagnose Leptomeningeal Metastases from Epithelial Tumors. Neuro Oncol 2017;19(9):1248-54
  • X Lin, M Lee, O Buck, KM Woo, Z Zhang, V Hatzoglou, A Omuro, J Arevalo-Perez, AA Thomas, J Huse, K Peck, AI Holodny, RJ Young. Diagnostic Accuracy of T1-Weighted DCE-MRI and DWI-ADC for Differentiation of Glioblastoma and Primary CNS Lymphoma. AJNR Am J Neuroradiol 2017;38(3):485-91
  • X Lin, WY Yu, L Liauw, RJ Chander, WE Soon, WY Lee, K Tan. Clinicoradiological Features Distinguish Tumefactive Multiple Sclerosis from CNS Neoplasms. Neurol Clin Pract 2017;7:1-12
  • PS Sachdev, JW Lo, JD Crawford, L Mellon, A Hickey, D Williams, R Bordet, AM Mendyk, P Gelé, D Deplanque, HJ Bae, JS Lim, A Brodtmann, E Werden, T Cumming, S Köhler, FR Verhey, YH Dong, HH Tan, C Chen, X Xin, RN Kalaria, LM Allan, RO Akinyemi, A Ogunniyi, A Klimkowicz-Mrowiec, M Dichgans, FA Wollenweber, V Zietemann, M Hoffmann, DW Desmond, T Linden, C Blomstrand, B Fagerberg, I Skoog, O Godefroy, M Barbay, M Roussel, BC Lee, KH Yu, J Wardlaw, SJ Makin, FN Doubal, FM Chappell, VK Srikanth, AG Thrift, GA Donnan, N Kandiah, RJ Chander, X Lin, C Cordonnier, S Moulin, C Rossi, B Sabayan, DJ Stott, JW Jukema, S Melkas, H Jokinen, T Erkinjuntti, VC Mok, A Wong, BY Lam, D Leys, H Hénon, S Bombois, DM Lipnicki, NA Kochan; STROKOG. STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimers Dement (Amst) 2016;18;7:11-23
  • X Lin, M Daras, E Pentsova, CP Nolan, IT Gavrilovic, LM DeAngelis, TJ Kaley. Bevacizumab in high grade glioma (HGG) patients following intraparenchymal hemorrhage (IPH). Neuro Oncol Pract 2016;0:1-5
  • EI Pentsova, RH Shah,  J Tang, A Boire, D You, S Briggs, A Omuro, X Lin, M Fleisher, C Grommes, KS Panageas, F Meng, SD Selcuku, S Ogilvie, N Distefano, L Shagabayeva, M Rosenblum, L DeAngelis, A Viale, IK Mellinghoff, MF Berger. Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid. J Clin Oncol. 2016;34(20):2404-2415.
  • N Kandiah, RJ Chander, X Lin, A Ng, YY Poh, CY Cheong, AR Cenina, PN Assam. Cognitive Impariment after Mild Stroke: Development and Validation of the SIGNAL2 Risk Score. J Alzheimers Dis. 2016;49:1169-77
  • N Kandiah, V Wang, X Lin, NN Nyu, L Lim, S Hameed, HL Wee. Cost Related to Dementia in the Young and the Impact of Etiological Subtype on Cost. J Alzheimers Dis. 2016;49:227-85
  • X Lin, L DeAngelis. Treatment of Brain Metastases. J Clin Oncol. 2015;33(30):3475-84
  • The Singapore Cancer Network (SCAN) Neuro-Oncology Workgroup. Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma. Ann Acad Med Singapore 2015;44:463-73
  • X Lin, WY Yu, G Priego, N CK Tan. Nodular nerves and lumpy leptomeninges – neuroimaging in primary leptomeningeal lymphoma. Neurol Asia 2014;19(4):421-3
  • X Lin, KE Lee. Numb Cheek Syndrome: A Clinical-Anatomical Correlation. Eur Neurol 2013;70:331-2
  • CJ Renaud, X Lin, S Subramanian, DA Fisher. High-dose cefazolin on consecutive hemodialysis in anuric patients with Staphylococcal bacteraemia. Hemodial Int. 2011;15:63-8
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Research Trials

  • A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 with Concurrent Chemoradiation and Adjuvant Temozolomide In Subjects with Newly Diagnosed Glioblastoma (GBM) with Epidermal Growth Factor Receptor (EGFR) Amplification (Intellance1) (NCT02573324), Co-Investigator 2017-present
  • A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to evaluate the efficacy and safety, of SA237 as Monotherapy in patients with Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD) (NCT02073279), Co-Investigator 2016-present
  • A Proof-of-Concept, Pilot Study of Pembrolizumab (MK-3475) in Patients with Recurrent Malignant Glioma with a Hypermutator Phenotype (NCT02658279), Investigator 2016-present