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Neurotherapeutics Laboratory

Shi-Yan Ng, Ph.D

Visiting Scientist, National Neuroscience Institute
Junior Investigator, Institute of Molecular and Cell Biology

Contact Information:

Institute of Molecular and Cell Biology
61 Biopolis Drive, 5-07
Proteos, Singapore 138673
Tel: 6586 9525
Website: http://www.imcb.a-star.edu.sg/php/iji-syn.php  

Team

  • Sherylin Hor Jin Hui, Research Officer
  • Hongbing Yu, Postdoc (co-supervised with Dr. Boon Seng Soh)

Overview of Laboratory

Our research program focuses on the biology of neurodegeneration. We are broadly interested in using human induced pluripotent stem cells to model neurodegenerative diseases such as Parkinson’s disease, Amyotrophic Lateral Sclerosis and dementia. Combining genomic technologies with drug screening and high content imaging, we aim to uncover mechanisms underlying specific neuronal vulnerability and how this knowledge can be used to prevent or treat human neurodegeneration.

We believe in collaborating with academic, industry and clinician partners to advance scientific knowledge. Some of our collaborators include Lee Rubin (Harvard Stem Cell Institute), Syros Pharmaceuticals (Cambridge, MA), National Neuroscience Institute, National University of Singapore and the Genome Institute of Singapore.

Selected Publications

  1. S Ounzain, R Micheletti R, C Arnan, I Plaisance, D Cecchi, B Schroen, F Reverter, M Alexanian, C Gonzales, SY Ng, G Bussotti, I Pezzuto, C Notredame, S Heymans, R Guigo, R Johnson, T Pedrazzini. CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis. (Advanced Online Publication: J Mol Cell Cardiol 27 September 2015)
  2. SY Ng, BS Soh, N Rodriguez-Muela, DG Hendrickson, FD Price, JL Rinn, LL Rubin. Genome-wide RNA-seq of human motor neurons implicates selective ER stress activation in Spinal Muscular Atrophy. (Advanced Online Publication: Cell Stem Cell 27 August 2015)
  3. BS Soh, K Buac, H Xu, E Li, SY Ng, H Wu, J Chmielowiec, X Jiang, L Bu, R Li, C Cowan, KR Chien (2014). N-cadherin prevents the premature differentiation of second heart field progenitors in the pharyngeal mesoderm microenvironment. Cell Res. 24: 1420-32.
  4. SY Ng, GK Bogu, BS Soh, LW Stanton (2013). The long non-coding RNA RMST interacts with SOX2 to regulate neurogenesis. Mol. Cell 51: 349-59.
  5. SY Ng, L Lin, BS Soh, LW Stanton (2013). Long non-coding RNAs in development and disease of the central nervous system. Trends in Genetics 29:461-8.
  6. SY Ng, LW Stanton (2013). Long non-coding RNAs in stem cell pluripotency. Wiley Interdiscip. Rev RNA 4: 121-8.
  7. BS Soh, D Zheng, JSL Yeo, HH Yang, SY Ng, LH Wong, W Zhang, P Li, M Nichane, A Asmat et al. (2012). CD166(pos) subpopulation from differentiated human ES and iPS cells support repair of acute lung injury. Mol. Ther. 20: 2335-46.
  8. SY Ng, R Johnson, LW Stanton (2012). Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J. 31: 522-533. Featured article and accompanied by Preview in EMBO J. 31: 515-516.
  9. X Jiang, HQ Cao, LY Shi, SY Ng, LW Stanton, SY Chew (2012). Nanofiber topography and sustained biochemical signaling enhance human mesenchymal stem cell neural commitment. Acta Biomater. 8: 1290-1302.