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Dothiepin

Drug Class: Commonly Known As: Category:
Tricyclic Antidepressants

Dothiepin - Side Effects, Precautions, and Contraindications

What side effects can Dothiepin cause?

The mentioned side effects generally affect up to 10% of patients.

  • Nausea or vomiting or loss of appetite
    • Take the medication with or after food.
    • Take small but frequent meals and avoid fatty or spicy food
  • Drowsiness or feeling tired
    • Avoid driving or taking part in activities that requires concentration. Discuss with your doctor if you can take your medication at a different time of the day if it affects you.
  • Dry mouth
    • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
  • Constipation
    • Drink more water (if you do not have any fluid restriction), eat more high- fibre foods, and exercise regularly
    • Consult your doctor or pharmacist if you need medication to relieve your condition.
  • Diarrhoea
    • Drink plenty of water to replace the loss of fluids
  • Dizziness
    • Get up slowly from a sitting or lying down position
  • Mild nervousness
    • May occur at the start of treatment and improves over time
  • Weight gain
    • Exercise regularly and eat a healthy and balanced diet
  • Headache, decreased sexual drive or ability
    • Speak to your doctor if any of these affect your daily life

Most of the side effects listed here will improve with time. Speak with your doctor if they continue, get worse or are affecting your daily life.

Very rarely (affect less than 1% of patients) this medication may cause:

  • Fast or irregular heartbeat
  • Confusion
  • Seeing or hearing things that are not there (hallucinations)
  • Stiffness of arms or legs
  • Problems in urinating
  • Blurred vision
  • Fits (seizures)
  • Yellowing of skin or eyes, pain in your upper stomach, dark brown urine and/or pale grey/clay-coloured stools (signs and symptoms of liver damage)

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Before taking Dothiepin, what precautions must I follow?

Inform your healthcare professional if:

  • You are allergic to this medication or any of the other ingredients of this medication
  • You are pregnant, planning to become pregnant, or breastfeeding. If you are pregnant and/or breastfeeding, your doctor would have discussed the potential benefits and side-effects with you and should you have further questions or concerns, do consult your doctor.
  • You have or have ever had:
    • Other drug allergies
    • Heart, kidney or liver disease
    • Medical conditions such as difficulty in urination, enlarged prostate gland, overactive thyroid gland (hyperthyroidism), fits (seizures) or increased eye pressure (glaucoma)
    • Other mental health conditions such as bipolar disorder, abnormally high or excited mood (mania) or alcohol abuse
    • Been taking other medications for low mood in the past 2 weeks.

Your skin may become more sensitive to sunlight after starting this medication. Avoid strong sunlight and use sunblock to protect your skin.

IMPORTANT:

In some cases, particularly in young people below the age of 25 years, this medication may cause the following changes to a person's mental condition, especially in the first few weeks of treatment or during dose changes:

  • New or worsening thoughts of harming yourself or ending your life
  • Worsening agitation, restlessness, violent behaviour, or
  • Other changes in mood or behaviour

Please inform your doctor as soon as possible, or for your family or caregiver to inform your doctor if you are unable to seek treatment on your own.

Do not stop taking this medication on your own without discussing with your doctor.

It is important to note that your doctor has prescribed this medication as he/she feels you will benefit more from taking this medication over the possible risks that it may cause, which have a low chance of occurring, and most people take this medication without any of such problems.

What food or medicine must I avoid when I take Dothiepin?

​Avoid drinking alcohol while taking this medication as it may make you feel very drowsy. This medication may interact with other medications. If you intend to take any over the counter medication, supplements, herbal remedy or traditional Chinese medicine, consult your doctor or healthcare professional first to confirm that it is safe to take with Dothiepin.

Dothiepin - Additional Information

  • Updated on Monday, May 31, 2021
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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