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Ambrisentan

Drug Class: Commonly Known As: Category:
Adult

Ambrisentan - What is it for

​Ambrisentan is used to treat pulmonary arterial hypertension. It is an endothelin receptor antagonist (ERA) that lowers the pressure in the pulmonary arteries (blood vessels in the lungs that transfer oxygen into the blood) by blocking the effects of endothelin. It may have the potential to reverse some of the damage done by the condition. This should also improve symptoms such as breathlessness and increase your ability to exercise.

This medication may also be used for other conditions as determined by your doctor.

Ambrisentan - Side Effects, Precautions, and Contraindications

What side effects can Ambrisentan cause?

​These side effects may be minimized by starting with a lower dose and may improve or go away with time. Inform your healthcare professional if it becomes bothersome or does not go away.

  •  Flushing, low blood pressure, fainting or headache
    • Rise slowly from a sitting or lying position to reduce giddiness when changing position
  • Leg swelling (oedema)
  • Flu-like symptoms such as nose and throat irritations, stuffy nose or back pain

Other rare but serious side effects include:

  • Changes in liver function: signs include dark urine or light coloured stools, nausea, vomiting, loss of appetite, stomach pain, yellowing of your eyes or skin.
  • Low haemoglobin levels (anaemia): signs include feeling more tired, weak or shortness of breath.

These side-effects are usually not significant, they are often treatable once detected early. You will need frequent blood tests to monitor for them.

If your experience any of these symptoms, you should stop your medication and see your healthcare professional immediately.

Ambrisentan may reduce fertility in men by reducing sperm count when taken for long term. Discuss with your healthcare professional if your have any concerns about it.

The symptoms of a drug allergy include one or more of the following:

  • Swollen face/eyes/lips/tongue
  • Difficulty in breathing
  • Itchy skin rashes over your whole body

Before taking Ambrisentan, what precautions must I follow?

​Inform your healthcare processional if:

  • You are allergic to this medication or any of the other ingredients of this medication.
  • You are pregnant, planning to become pregnant, or breastfeeding.
    • As this medication may cause birth defects, female patients of childbearing age should take precautions by using at least 2 reliable methods of contraception to avoid pregnancy. If you suspect you may be pregnant, inform your doctor as soon as possible.
    • You should not become pregnant for at least 1 month after stopping this medication.
  • You have or have had liver or kidney disease.
  • You have a condition called idiopathic pulmonary fibrosis (IPF), whereby there is scarring in your lungs.
  • You are taking any other medications, including supplements, traditional medications and herbal remedies

What food or medicine must I avoid when I take Ambrisentan?

​Some medications may interact with Ambrisentan and affect their effectiveness or increase the risk of side-effects. However, these medications may also be important for your treatment. Inform your healthcare professional of the other medications you are currently taking. Examples include:

  • Cyclosporine, a medication for suppression of the immune system
  • Medications for bacterial infections (e.g. clarithromycin, erythromycin)
  • Medications for fungal infections (e.g. itraconazole, ketoconazole)

Consult your healthcare professional if your are unsure whether your existing medications can be taken together with this medication.

Ambrisentan - Dosage and How to Use

How should Ambrisentan be used?

  • ​Do not stop taking your medication without checking with your healthcare professional as it may make your condition worse.
  • You may take this with or without food.
  • This medication is initially started at a lower dose. Your condition will be monitored closely. Your doctor may later adjust your dosage to better control your condition.

What should I do if I miss a dose?

​If your forget to take a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose.

What should I do if I overdose?

​If your take more than the recommended dose, please seek medical advice immediately. The information provided on this page does not replace information from your healthcare professional. Please consult your healthcare processional for more information.

Ambrisentan - Handling

How should I handle Ambrisentan safely?

Ambrisentan - Storage

How should I store Ambrisentan?

Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

How should I dispose of Ambrisentan safely?

​Pack this medication into a black trash bag and seal it tightly before throwing into the rubbish chute or bin.

Ambrisentan - Additional Information

  • Updated on Wednesday, October 28, 2020
  • Article contributed by PSS National Medication Information Workgroup PSS National Medication Information Workgroup

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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