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Research > Research Laboratories > Liao Ping

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LIAO Ping, Ph.D.                                                                                        
Principal Investigator and Head
Calcium Signaling Laboratory                                                                            
National Neuroscience Institute
11 Jalan Tan Tock Seng
Singapore 308433
Tel: (65) 6357-7611 (Office)
      (65) 6357-7615 (Lab)
Fax:(65) 6256-9178
Email : ping_liao@nni.com.sg

EDUCATION

1997-2001 Ph.D. National University of Singapore

1989-1996 Bachelor of Medicine, Master of Surgery (Neurosurgery)

West China University of Medical Sciences, Sichuan, China.

RESEARCH AREAS

Calcium is universally used throughout phylogeny and by all cell types for signal transduction. Spatially and temporally controlled changes in calcium concentration are critical to the normal function of cells. Calcium enters the cell via calcium-permeable ion channels spanning plasma membrane. Our research work focuses on the physiology and pathophysiology of ion channels in the central nervous system (CNS), particularly transient receptor potential (TRP) channels and voltage-gated calcium channels. Currently, we are investigating stroke, cerebral ischemia and other CNS disorders.

SELECTED PUBLICATIONS

Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW. Splice Variant Specific Modulation of CaV1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction. Circ Res. 2011 Nov 11;109(11):1250-8.

Zhang HY, Liao P, Yu D, Soong TW. Alternative splicing of Cav1.2 channels determines the
diltiazem sensitivity between cardiac and smooth muscle. British Journal of Pharmacology 2010 Aug;160(7):1631-40. (Joint first author).

Liao P, Soong TW. Cav1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. European Journal of Physiology (Pflugers Arch) 2010 Jul;460(2):353-9. (Invited Review, Corresponding author)

Liao P, Li G, Yu D, Yong TF, Wang J, Soong TW. Molecular alteration of Cav1.2 calcium channel in chronic myocardial infarction. European Journal of Physiology (Pflugers Arch) 2009 Aug;458(4):701-11.

Liao P, Zhang HY, Soong TW. Alternative splicing of voltage-gated calcium channels: from molecular biology to disease. European Journal of Physiology (Pflugers Arch). 2009 Jul;458(3):481-7.

Tao J, Hildebrand ME, Liao P, Liang MC, Tan G, Li S, Snutch TP, Soong TW. Activation of corticotropin-releasing factor receptor 1 selectively inhibits Cav3.2 T-type calcium channels. Mol Pharmacol. 2008 Jun;73(6):1596-609

Tang ZZ, Liao P, Li G, Jiang FL, Yu D, Hong X, Yong TF, Tan G, Lu S, Wang J, Soong TW. Differential Splicing Patterns of L-Type Calcium Channel Cav1.2 Subunit in Hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. Biochim Biophys Acta.-MOL CELL RES. 2008 Jan;1783(1):118-30

Liao P, Yu D, Li G, Yong TF, Soon JL, Chua YL, Soong TW. A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine. J Biol Chem. 2007 Nov 30;282(48):35133-42.

Shen Y, Yu D, Hiel H, Liao P, Yue DT, Fuchs PA, Soong TW. Alternative splicing of the Cav1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells. J Neurosci. 2006 Oct 18;26(42):10690-9.

Liao P, Yong TF, Liang MC, Yue DT, Soong TW. Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles. Cardiovasc Res. 2005 Nov 1;68(2):197-203.

Liao P, Yu D, Lu S, Tang ZZ, Liang MC, Zeng S, Lin W, Soong TW. Smooth muscle selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels. J Biol Chem. 2004 Nov 26;279(48):50329-35.

TEAM MEMBERS

Dr. Loh Kok Poh
Dr. Purnima Sharma
Ms. Yu Chye Yun
Mr. Fhu Chee Kong
Mr. Gandi